Protective effect of alpha lipoic acid on cisplatin induced hepatotoxicity in rats

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dc.contributor.authorPinar, Neslihan
dc.contributor.authorCakirca, Gokhan
dc.contributor.authorHakverdi, Sibel
dc.contributor.authorKaplan, Mahir
dc.date.accessioned2024-09-18T19:52:38Z
dc.date.available2024-09-18T19:52:38Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractWe investigated the protective effect of alpha lipoic acid (ALA) against cisplatin (CIS) induced hepatotoxicity in rats. ALA is an antioxidant and anti-inflammatory agent that exhibits free radical scavenger properties and direct antioxidant effects on recycling of other cellular antioxidants. We used four equal groups of rats. The control group: saline solution (0.9%) was administered intraperitoneally (i.p.); ALA group: administered a single dose 100 mg/kg ALA i.p. for 10 days; CIS group was administered a single dose 5 mg/kg CIS i.p. on the first day of the study; CIS + ALA group was administered a single dose 5 mg/kg CIS i.p. on the first day of study, then 100 mg/kg ALA i.p. for 10 days. In the CIS group, Bax, caspase3, malondialdehyde (MDA), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were increased, whereas Bcl-2, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) levels were decreased compared to the control group. In the CIS + ALA group, Bax, caspase 3, MDA, AST and ALT levels were decreased, whereas Bcl-2, SOD, CAT and GPx levels were increased compared to the CIS group. In the CIS group we found intense perivenule sinusoid dilation, karyomegaly, pyknotic and karyolytic cells, central vein congestion, parenchymal inflammation, mild bile duct proliferation and periportal sinusoid dilation. Histological liver damage was reduced in the CIS + ALA group. ALA may useful for treating CIS induced hepatotoxicity owing to its antioxidant and anti-inflammatory effects.en_US
dc.identifier.doi10.1080/10520295.2019.1667025
dc.identifier.endpage224en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue3en_US
dc.identifier.pmid31687838en_US
dc.identifier.scopus2-s2.0-85074849014en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage219en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2019.1667025
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7570
dc.identifier.volume95en_US
dc.identifier.wosWOS:000494399100001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectalpha lipoic aciden_US
dc.subjectapoptosisen_US
dc.subjectcisplatinen_US
dc.subjecthepatotoxicityen_US
dc.subjectoxidative stressen_US
dc.subjectratsen_US
dc.titleProtective effect of alpha lipoic acid on cisplatin induced hepatotoxicity in ratsen_US
dc.typeArticleen_US

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