Evaluation of the efficacy of several sclerosing agents for pleurodesis in rats

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dc.authoridkuzucuoglu, mustafa/0000-0001-9889-0061
dc.authoridYekdes, Ali Cem/0000-0002-8928-2053
dc.authoridbalta, cenk/0000-0002-4073-8101
dc.contributor.authorBalta, Cenk
dc.contributor.authorKuzucuoglu, Mustafa
dc.contributor.authorAslan, Figen
dc.contributor.authorYekdes, Ali Cem
dc.date.accessioned2024-09-18T20:54:18Z
dc.date.available2024-09-18T20:54:18Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: This study aims to evaluate the efficiencies and effects of different sclerosing agents. Materials and Methods: Thirty-five female Wistar-albino rats were included in this study and divided into five groups randomly. Isotonic saline (group 1), iodopovidone (group 2), rifamycin (group 3), autologous blood (group 4), talc (group 5) were given into intrapleural space. On postoperative 28th day, ipsilateral and contralateral pleural and parenchymal fibrosis and inflammation were evaluated. Results: There were statistically differences between control and other groups on macroscopically pleural fibrosis examination (p=0.004, p=0.001, p=0.001, p=0.000, respectively). Microscopically pleural fibrosis were determined in all groups when compared to control group (p=0.023, p=0.023, p=0.035, p=0.001, respectively). There were no significant differences between sclerosing agent groups (p>0.05). Significant differences were observed according to microscopic pleural inflammation evaluation between talc group and other groups. There was superiority in talc group according to intraparenchymal inflammation grade compared to other groups (p=0.010, p=0.042, p=0.030, respectively). Macroscopically, fibrosis and microscopically, inflammation were significantly observed between talc and other groups in the contralateral pleura (p=0.037and p=0.009, respectively). Conclusion: lodopovidonc, autologous blood, talc, and rifamycin can be used as effective pleurodesis agents. However, we found that rifamycin and autologous blood are safer as effective pleurodesis agents. We think that these two agents can be used in patients with secondary lung diseases due to their less intraparenchymal inflammation rates. It may be advantageous to prefer other sclerosing agents which has lower costs and less side effects comparing to talc.en_US
dc.identifier.doi10.5472/marumj.1191101
dc.identifier.endpage302en_US
dc.identifier.issn1309-9469
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85141423158en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage297en_US
dc.identifier.urihttps://doi.org/10.5472/marumj.1191101
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11733
dc.identifier.volume35en_US
dc.identifier.wosWOS:000878860500005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMarmara Univ, Fac Medicineen_US
dc.relation.ispartofMarmara Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPleurodesisen_US
dc.subjectPleural effusionsen_US
dc.subjectPleural inflammationen_US
dc.subjectAnimal experimentsen_US
dc.titleEvaluation of the efficacy of several sclerosing agents for pleurodesis in ratsen_US
dc.typeArticleen_US

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