Protective Effect of Hypericum perforatum Extract on Methotrexate-Induced Osteotoxicity via Reducing Oxidative Stress and MAPK Activity

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dc.contributor.authorUruc, Vedat
dc.contributor.authorSalimov, Fariz
dc.contributor.authorKaplan, Halil Mahir
dc.date.accessioned2024-09-18T20:32:54Z
dc.date.available2024-09-18T20:32:54Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackgrounds and Objective: Methotrexate (MTX) is an anti-metabolite and anti-rheumatic drug that is widely used in cancer treatment. It is known that a high dose of MTX chemotherapy causes bone growth disturbance in developing bones. Hypericum perforatum (HP) plant is useful against some diseases for local people and regulates apoptosis which is also known as programmed cell death and recent studies also reported that HP reduces the side effects of many toxic drugs. For this reason, we planned a study to reveal the osteoprotective effect of HP extract against MTX induced osteo-toxicity. Materials and Methods: For this purpose MLO-Y4 cells were cultured, then these cells were treated with HP and methotrexate and mediators of the apoptotic, MAPK pathway and the oxidative stress parameters were analyzed on these cells. Results: Expression of proapoptotic factors increased and expression of antiapoptotic factors were decreased with MTX treatment. Treatment of HP ameliorated the apoptotic effect of MTX on MLO-Y4 cells. HP treatment also inhibited MAPK activity and oxidative stress induced by methotrexate. Conclusion: HP attenuated methotrexate-ind uced osteo-toxicity via reducing oxidative stress and MAPK activity and HP is an effective reducing side effect of MTX.en_US
dc.identifier.doi10.3923/ijp.2020.430.436
dc.identifier.endpage436en_US
dc.identifier.issn1811-7775
dc.identifier.issn1812-5700
dc.identifier.issue5en_US
dc.identifier.startpage430en_US
dc.identifier.urihttps://doi.org/10.3923/ijp.2020.430.436
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11199
dc.identifier.volume16en_US
dc.identifier.wosWOS:000582276000006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherAsian Network Scientific Information-Ansineten_US
dc.relation.ispartofInternational Journal of Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMLO-Y4en_US
dc.subjectHypericum perforatumen_US
dc.subjectmethotrexateen_US
dc.subjectapoptosis and oxidative stressen_US
dc.titleProtective Effect of Hypericum perforatum Extract on Methotrexate-Induced Osteotoxicity via Reducing Oxidative Stress and MAPK Activityen_US
dc.typeArticleen_US

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