Effect of intravitreal injection of dexamethasone implant on corneal endothelium in macular edema due to retinal vein occlusion

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dc.contributor.authorIlhan, Nilufer
dc.contributor.authorCoskun, Mesut
dc.contributor.authorIlhan, Ozgur
dc.contributor.authorTuzcu, Esra Ayhan
dc.contributor.authorDaglioglu, Mutlu Cihan
dc.contributor.authorElbeyli, Ahmet
dc.contributor.authorKeskin, Ugurcan
dc.date.accessioned2024-09-18T19:54:26Z
dc.date.available2024-09-18T19:54:26Z
dc.date.issued2015
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: To evaluate the effects of dexamethasone (DEX) implant (Ozurdex(R)) on corneal endothelium in patients with retinal vein occlusion complicated with macular edema. Materials and methods: Patients (n = 31) received 1-3 intravitreal DEX implants in one eye. Measurements were intraocular pressure (IOP) at baseline and 1, 3, and 6 months after the first intravitreal injection and corneal specular microscopy and central corneal thickness (CCT) at baseline and 1 and 6 months. We analyzed endothelial cell density (ECD), coefficient of variation of cell size (CV), and percentage of hexagonality. Results: Mean follow-up period was 9.7 +/- 3.3 months. Mean number of injections was 1.5 +/- 0.8. Mean IOP values were 15.6 +/- 2.6mm Hg at baseline, 17.7 +/- 3.6mm Hg at one month, 16.4 +/- 4.1mm Hg at three months, and 16.0 +/- 2.7mm Hg at six months. There was a significant difference in mean IOPs at one month and six months (p = 0.008). There were no significant differences in mean ECD (p = 0.375), CV (p = 0.661), percentage of hexagonality (p = 0.287), and CCT (p = 0.331). Conclusion: Although intravitreal injection of 0.7mg DEX causes moderate elevation of IOP, it does not seem to have detrimental effects on corneal endothelium at six months.en_US
dc.identifier.doi10.3109/15569527.2014.975242
dc.identifier.endpage297en_US
dc.identifier.issn1556-9527
dc.identifier.issn1556-9535
dc.identifier.issue4en_US
dc.identifier.pmid25347799en_US
dc.identifier.scopus2-s2.0-84946064763en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage294en_US
dc.identifier.urihttps://doi.org/10.3109/15569527.2014.975242
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7732
dc.identifier.volume34en_US
dc.identifier.wosWOS:000371395000006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofCutaneous and Ocular Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnterior eye segmenten_US
dc.subjectcorticosteroiden_US
dc.subjectdrug delivery systemsen_US
dc.titleEffect of intravitreal injection of dexamethasone implant on corneal endothelium in macular edema due to retinal vein occlusionen_US
dc.typeArticleen_US

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