Effects of Sildenafil Citrate, Isoniazid, and Streptomycin on Testicular Tissue and Epididymal Semen Quality in Rats

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dc.authoridTas, Muzaffer/0000-0002-5143-7208
dc.authoridSeker, Ugur/0000-0002-1693-6378
dc.contributor.authorAlp, Harun
dc.contributor.authorCirit, Umut
dc.contributor.authorTas, Muzaffer
dc.contributor.authorRifaioglu, Murat Mehmet
dc.contributor.authorHatipoglu, Namik Kemal
dc.contributor.authorAytekin, Ismail
dc.contributor.authorYucel, Mehmet
dc.date.accessioned2024-09-18T21:03:11Z
dc.date.available2024-09-18T21:03:11Z
dc.date.issued2012
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractOBJECTIVE To evaluate the effects of isoniazid (INH) and streptomycin (STR) on epididymal semen quality and testicular tissue, and to evaluate the protective effect of sildenafil citrate (SC) on possible testicular toxicity induced by STR and INH in rats. METHODS Eighty adult male Sprague-Dawley rats were divided randomly into 8 groups including control, SC, INH, STR, STR + INH, SC + INH, SC + STR, and SC + INH + STR. After 45 days of treatment, the reproductive organ weights, epididymal semen quality, testicular histopathological findings, levels of serum nitric oxide, testosterone, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) were investigated. RESULTS SC significantly increased the epididymal sperm motility and concentration, and the levels of FSH, LH, and testosterone. The STR group had a significantly higher percentage of sperm head defect than the control group (P < .05). The INH group had lower Johnsen Testicular Biopsy Score than the control group (P < .001). Although SC and INH treatment alone did not affect the epididymal semen quality negatively, the SC + INH group had significantly higher spermatozoon tail and total morphologic defect ratios than the control group (P < .05). CONCLUSION It has been concluded from this study that (1) SC has positive effects on spermatogenesis, sperm production, and semen quality; (2) STR affected the testicular biopsy score and spermatozoon head morphology negatively, but positively affected the other spermatologic traits; (3) INH did not effect the epididymal semen quality negatively, but decreased testicular biopsy score; and (4) SC can prevent the spermatozoon head defects induced by STR and can decrease the testicular toxicity induced by INH. UROLOGY 80: 953.e9-953.e14, 2012. (C) 2012 Elsevier Inc.en_US
dc.identifier.doi10.1016/j.urology.2012.05.016
dc.identifier.issn0090-4295
dc.identifier.issue4en_US
dc.identifier.pmid22840858en_US
dc.identifier.scopus2-s2.0-84866739600en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.urology.2012.05.016
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13294
dc.identifier.volume80en_US
dc.identifier.wosWOS:000309518700062en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofUrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGenital Tuberculosisen_US
dc.subjectBurdenen_US
dc.subjectDamageen_US
dc.subjectModelen_US
dc.titleEffects of Sildenafil Citrate, Isoniazid, and Streptomycin on Testicular Tissue and Epididymal Semen Quality in Ratsen_US
dc.typeArticleen_US

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