Low serum levels of vitamin D in metastatic cancer patients: a case-control study

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dc.authoridSumbul, Ahmet Taner/0000-0002-5573-906X
dc.authoridsezer, ahmet/0000-0002-6445-1439
dc.authoridUstun, Ihsan/0000-0002-5848-1586
dc.contributor.authorSumbul, Ahmet Taner
dc.contributor.authorSezer, Ahmet
dc.contributor.authorKavvasoglu, Gamze
dc.contributor.authorBatmaci, Celal Yucel
dc.contributor.authorYengil, Erhan
dc.contributor.authorYagiz, Abdullah Erman
dc.contributor.authorGultepe, Ihami
dc.date.accessioned2024-09-18T20:32:49Z
dc.date.available2024-09-18T20:32:49Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAccompanying comorbidities observed during the cancer treatment usually affect the course and outcome of the therapy. Hypovitaminosis D, which is one of these conditions, is a resolvable problem, if recognized. In this study, we investigated whether the serum 25(OH) D levels of the patients who were presented to our outpatient clinic were different from the serum levels of the healthy population living in the same area. Our study included 90 patients who were presented to the Medical Oncology outpatient clinic and 90 age, gender, body mass index and ethnic origin matched controls without a known disease, who were presented to the outpatient clinics of the Departments of Internal Diseases and Family Medicine for routine controls. Blood count tests, detailed biochemistry tests (including serum levels of Cr, Ca and P), measurement of serum 25(OH) D levels and C-reactive protein were performed in serum samples of all of the patients and controls. Mean serum levels of 25(OH) D were 13.5 ng/ml (SD 5.1) in all cancer patients, 13.1 ng/ml (SD 4.2) in the patients who were presented for adjuvant therapy, 13.8 ng/ml (SD 5.5) in the patients who were presented at metastatic stage and 18.4 ng/ml (SD 12.5) in the controls. Mean serum CRP levels were 5.4 mg/dl (SD 1.2) in the control group, 8.4 mg/dl (SD 4.3) in the adjuvant therapy group and 20.3 (SD 16.8) in the patients with metastatic disease. Generally, all cancer patients (p 0.003) and the patients with metastatic cancer (p 0.004) had lower serum 25(OH) D levels compared to controls, and there was an inverse correlation between serum 25(OH) D and CRP levels in patients with metastatic cancer (p 0.036). In metastatic cancer patients, hypovitaminosis D may be a comorbidity and it is recommended to consider during initial evaluation and follow-up. Because it might improve these patients quality of life and chemotherapy adherence.en_US
dc.identifier.doi10.1007/s12032-014-0861-3
dc.identifier.issn1357-0560
dc.identifier.issn1559-131X
dc.identifier.issue3en_US
dc.identifier.pmid24493144en_US
dc.identifier.scopus2-s2.0-84893168261en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1007/s12032-014-0861-3
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11143
dc.identifier.volume31en_US
dc.identifier.wosWOS:000337728700027en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofMedical Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMetastatic canceren_US
dc.subjectSerum 25(OH)D levelsen_US
dc.subjectComorbid conditionsen_US
dc.subjectInflammationen_US
dc.titleLow serum levels of vitamin D in metastatic cancer patients: a case-control studyen_US
dc.typeArticleen_US

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