The Neuroprotective and Anti-inflammatory Effects of Diltiazem in Spinal Cord Ischaemia-Reperfusion Injury

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dc.authoridDUMAN, Taskin/0000-0002-6552-4193
dc.contributor.authorFansa, I.
dc.contributor.authorAltug, M. E.
dc.contributor.authorMelek, I.
dc.contributor.authorUcar, E.
dc.contributor.authorKontas, T.
dc.contributor.authorAkcora, B.
dc.contributor.authorAtik, E.
dc.date.accessioned2024-09-18T20:15:08Z
dc.date.available2024-09-18T20:15:08Z
dc.date.issued2009
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe protective effects of diltiazem were examined in a rabbit model of spinal cord ischaemia-reperfusion induced by infrarenal aortic occlusion for 30 min. In the diltiazem group (n = 6), an intravenous infusion (2 mu g/kg per min) was started 10 min before ischaemia induction; normal saline solution was infused in the control group (n = 6). Neurological function was assessed using modified Tarlov criteria 24 h after surgery. Plasma samples were analysed for interleukin (IL)-6 and IL-10. Spinal tissue was analysed for malondialdehyde, nitric oxide and reduced glutathione activities. Tarlov scores of the diltiazem-treated rabbits indicated significantly improved hind-limb motor function compared with the control group. The diltiazem group also had better quantitative and qualitative histopathological findings. Diltiazem infusion significantly reduced IL-6 levels 3 and 24 h after reperfusion compared with the control group. The mean IL-10 level in the diltiazem group was significantly higher than in the control group 24 h after reperfusion. It is concluded that diltiazem has cytoprotective and anti-inflammatory properties, leading to reduced spinal cord injury.en_US
dc.identifier.doi10.1177/147323000903700228
dc.identifier.endpage533en_US
dc.identifier.issn0300-0605
dc.identifier.issue2en_US
dc.identifier.pmid19383247en_US
dc.identifier.scopus2-s2.0-66649095947en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage520en_US
dc.identifier.urihttps://doi.org/10.1177/147323000903700228
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9465
dc.identifier.volume37en_US
dc.identifier.wosWOS:000267907600028en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherField House Publishing Llpen_US
dc.relation.ispartofJournal of International Medical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDILTIAZEMen_US
dc.subjectSPINAL CORD ISCHAEMIAen_US
dc.subjectANIMAL MODELen_US
dc.subjectINFLAMMATORY CYTOKINESen_US
dc.subjectFREE RADICALSen_US
dc.titleThe Neuroprotective and Anti-inflammatory Effects of Diltiazem in Spinal Cord Ischaemia-Reperfusion Injuryen_US
dc.typeArticleen_US

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