Investigation of relationship between IL-6 gene variants and hypertension in Turkish population

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dc.authoridGuler, Halil Ibrahim/0000-0002-7261-6790
dc.authoridUZUN GOCMEN, Semire/0000-0003-0783-6014
dc.authoridBAYRAMOGLU, AYSEGUL/0000-0001-8567-807X
dc.contributor.authorKaraman, Esin
dc.contributor.authorKucuk, Meral Urhan
dc.contributor.authorBayramoglu, Aysegul
dc.contributor.authorGocmen, Semire Uzun
dc.contributor.authorErcan, Suleyman
dc.contributor.authorGuler, Halil Ibrahim
dc.contributor.authorKucukkaya, Yunus
dc.date.accessioned2024-09-18T20:27:56Z
dc.date.available2024-09-18T20:27:56Z
dc.date.issued2015
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractHypertension (HT) is a common and life threating health problem worldwide leading to stroke, heart attack and renal failure. It is characterized by elevated blood pressure forced heart load. Human interleukin-6 (IL-6) and C- reactive protein (CRP) are known to be involved in inflammatory processes. IL-6 gene is a polymorphic gene which -174 G/C is a common and -572 G/C is a rare polymorphisms identified in promoter region. Publications on IL-6 gene polymorphisms raised the question whether this gene polymorphisms lead to susceptibility to HT or not. To investigate the effects of IL-6 gene -174 G/C (rs 1800795) and -572 G/C (rs1800796) polymorphisms on plasma IL-6 and CRP levels and their associations with hypertension disease in Turkish population we analyzed -174 G/C and -572 G/C polymorphisms and plasma IL-6 and CRP levels in 111 healthy controls and 108 hypertension patients from Adyaman, Turkey. We determined the genotypes using polymerase chain reaction-restriction fragment length polymorphism and analyzed plasma levels of IL-6 by ELISA and CRP by automated standard biochemical methods. We have found no statistically significant differences between IL-6 gene -174 G/C and -572 G/C genotypes and allelic frequencies and IL-6 and CRP plasma levels and HT (p > 0.05). No CC genotype was found in control subjects for -572 G/C polymorphism. In conclusion, we found relation to -174 G/C and -572 G/C gene variants between neither IL-6 and CRP levels nor hypertension. The -572 G allele and GG genotype are predominant in Turkish population in Adyaman, Turkey whereas the CC genotype is very rare.en_US
dc.description.sponsorshipResearch Foundation of Adiyaman University, Turkey [FEFYL/2012-0002]en_US
dc.description.sponsorshipThis study was supported by a grant of the Research Foundation of Adiyaman University (FEFYL/2012-0002), Turkey.en_US
dc.identifier.doi10.1007/s10616-014-9732-1
dc.identifier.endpage954en_US
dc.identifier.issn0920-9069
dc.identifier.issn1573-0778
dc.identifier.issue6en_US
dc.identifier.pmid24811130en_US
dc.identifier.scopus2-s2.0-84946474382en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage947en_US
dc.identifier.urihttps://doi.org/10.1007/s10616-014-9732-1
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10611
dc.identifier.volume67en_US
dc.identifier.wosWOS:000364225200004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofCytotechnologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHypertensionen_US
dc.subjectIL-6 gene polymorphismen_US
dc.subject-174 G/C,-572 G/C gene variantsen_US
dc.subjectCRPen_US
dc.titleInvestigation of relationship between IL-6 gene variants and hypertension in Turkish populationen_US
dc.typeArticleen_US

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