Impact and Diversity of ESBL-Producing Klebsiella pneumoniae Recovered from Raw Chicken Meat Samples in Türkiye

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dc.contributor.authorKuerekci, Cemil
dc.contributor.authorUenaldi, Oezlem
dc.contributor.authorSahin, Seyda
dc.contributor.authorGarcia-Menino, Isidro
dc.contributor.authorHammerl, Jens Andre
dc.contributor.authorAvbersek, Jana
dc.date.accessioned2024-09-18T20:33:00Z
dc.date.available2024-09-18T20:33:00Z
dc.date.issued2024
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe interrelationship between human, animal and environmental sectors leads to the spread of antibiotic resistance due to selective pressures, evolutionary traits and genomic evolution. In particular, the frequent use of antibiotics in livestock inevitably influences the emergence of specific resistance determinants in human strains, associated with reduced treatment options in clinical therapy. In this study, ESBL-producing Klebsiella pneumoniae strains isolated from chicken meat samples were evaluated for public health implications in Turkiye. Whole-genome sequencing was used for genetic dissection and phylogenetic comparison of their genomes. The isolates were assigned to four MLST types (ST147, ST37, ST2747 and ST219); two of them were found to represent the ST147 clone associated with severe human infections worldwide. In addition to cephalosporins, high resistance levels to quinolones/fluoroquinolones were identified phenotypically, caused by acquired resistance genes and chromosomal point variations. One isolate was also found to carry the qacE increment 1 efflux transporter gene, which confers tolerance to quaternary ammonium compounds. The detection of virulence genes (i.e., that coding for enterobactin) associated with the pathogenicity of K. pneumoniae suggests a public health impact. Thus, comprehensive information on the occurrence and impact of K. pneumoniae from livestock is needed to derive appropriate management strategies for consumer protection. In this study, it was shown that poultry meat serves as a reservoir of clinically emerging multidrug-resistant high-risk clones.en_US
dc.description.sponsorshipGerman Federal Institute for Risk Assessment (BfR)en_US
dc.description.sponsorshipThe technical support of Silvia Schmoger for WGS is highly appreciated.en_US
dc.identifier.doi10.3390/antibiotics13010014
dc.identifier.issn2079-6382
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85183126926en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3390/antibiotics13010014
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11255
dc.identifier.volume13en_US
dc.identifier.wosWOS:001151782900001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofAntibiotics-Baselen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectmultidrug resistanceen_US
dc.subjectK. pneumoniaeen_US
dc.subjectOne Healthen_US
dc.subjectfooden_US
dc.subjectzoonosisen_US
dc.subjectrisk evaluationen_US
dc.subjectconsumer protectionen_US
dc.titleImpact and Diversity of ESBL-Producing Klebsiella pneumoniae Recovered from Raw Chicken Meat Samples in Türkiyeen_US
dc.typeArticleen_US

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