Expression of E-cadherin in squamous cell carcinomas of the cervix with correlations to clinicopathological features

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dc.authorscopusid6701568675
dc.authorscopusid6602385478
dc.authorscopusid6701368587
dc.authorscopusid8889752000
dc.contributor.authorYaldiz, M.
dc.contributor.authorHakverdi, A.U.
dc.contributor.authorBayhan, G.
dc.contributor.authorAkkuş, Z.
dc.date.accessioned2024-09-19T15:45:28Z
dc.date.available2024-09-19T15:45:28Z
dc.date.issued2005
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: To evaluate the expression of E-cadherin, a calcium-dependent cell adhesion molecule, in a retrospective analysis of paraffin-embedded tissue specimens of cervical squamous carcinoma and the relationship with histopathological differentiation and lymph node status. Methods: In this study, we investigated by immunohistochemistry E-cadherin expression in ten normal cervical epithelia and 24 cervical invasive squamous carcinomas. Results: Normal cervical squamous epithelium showed strong expression of E-cadherin at the membrane of the cell and intercellular junctions. In 24 tumors immunnostained by E-cadherin antibody, 11 (46%) showed preserved expression and 13 (54%) reduced expression. There was no significant correlation between E-cadherin expression and histological differentiation (p = 0.650, p = 0.294). In the status of lymph node metastasis, reduced expression of E-cadherin was seen in 11/15 (73%) with lymph node metastasis versus 2/9 (22%) without lymph node metastasis. There was a significant inverse correlation between E-cadherin expression and lymph node metastasis (p = 0.032). Conclusion: Reduced E-cadherin expression may be an important factor among a variety of biologic events that occur during the process of metastasis. However, this should be explored by a large scale study.en_US
dc.identifier.endpage98en_US
dc.identifier.issn0392-2936
dc.identifier.issue1en_US
dc.identifier.pmid15755011en_US
dc.identifier.scopus2-s2.0-14644411009en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage95en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14711
dc.identifier.volume26en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofEuropean Journal of Gynaecological Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCervixen_US
dc.subjectE-cadherinen_US
dc.subjectSquamous cell carcinomaen_US
dc.titleExpression of E-cadherin in squamous cell carcinomas of the cervix with correlations to clinicopathological featuresen_US
dc.typeArticleen_US

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