Antioxidant activities of inula viscosa extract and curcumin on U87 cells induced by beta-amyloid

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dc.authoridAlizade, Ares/0000-0003-0334-8152
dc.contributor.authorAlizade, Ares
dc.contributor.authorOzbolat, Guluzar
dc.date.accessioned2024-09-18T20:28:02Z
dc.date.available2024-09-18T20:28:02Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Ãœniversitesien_US
dc.description.abstractPurpose: The aim of this study was to investigate the effects of Inula viscosa extract and Curcumin on the U87 (human astrocytoma cell line) treated with amyloid-beta (A beta), which is the Alzheimer's disease (AD) model cell line. Materials and Methods: Firstly, the cytotoxic potential of inula and curcumin was investigated in the U87 cells by the colorimetric MF1 (3-4,5-dimethyl-thiazolyl-2,5-diphenyltetrazolium bromide) assay. Then, the amount of Total Glutathione, Malondialdehyde (MDA), Glutathione reductase (GR) activities were investigated. ELISA test was used to examine the expression and activity of cleaved Bax and Bcl-2 proteins in the Inula viscosa and Curcumin treated U87 cell lines. Results: Inula viscosa and Curcumin treatment reduced cell death caused by amyloid-B in cells. It also reduced oxidative stress caused by amyloid-B, while reducing the activation of the proapoptotic protein Bax, and Bcl-2. Conclusion: Our results suggest that inula viscosa may represent a new approach in the treatment of Alzheimer's.en_US
dc.description.sponsorshipMustafa Kemal University Research Projects Unit [17.M.003]en_US
dc.description.sponsorshipThis study was funded by Mustafa Kemal University Research Projects Unit (Project No.: 17.M.003).en_US
dc.identifier.doi10.17826/cumj.854213
dc.identifier.endpage588en_US
dc.identifier.issn2602-3032
dc.identifier.issn2602-3040
dc.identifier.issue2en_US
dc.identifier.startpage583en_US
dc.identifier.urihttps://doi.org/10.17826/cumj.854213
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10698
dc.identifier.volume46en_US
dc.identifier.wosWOS:000694865200022en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherCukurova Univ, Fac Medicineen_US
dc.relation.ispartofCukurova Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInula viscosaen_US
dc.subjectcurcuminen_US
dc.subjectAlzheimeren_US
dc.subjectU87en_US
dc.subjectBaxen_US
dc.subjectBcl-2en_US
dc.titleAntioxidant activities of inula viscosa extract and curcumin on U87 cells induced by beta-amyloiden_US
dc.typeArticleen_US

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