Methyl parathion-induced changes in free and protein-bound SH levels in rat tissues

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dc.authoridYILDIZ, Hasan/0000-0001-5486-4005
dc.authoridDalkilic, Semih/0000-0002-6892-247X
dc.contributor.authorYildiz, Deniz
dc.contributor.authorDalkilic, Semih
dc.contributor.authorYildiz, Hasan
dc.contributor.authorOztas, Haydar
dc.date.accessioned2024-09-18T20:25:13Z
dc.date.available2024-09-18T20:25:13Z
dc.date.issued2006
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe main objective of this study was to investigate the changes in free and protein-bound SH contents in methyl parathion-exposed rat tissues. The free and protein-bound SH levels are usually affected and depleted by oxidative stress-inducing agents. Results would indicate if methyl parathion toxicity partly results from depletion of sulfhydryl content of tissues. Six-week-old male Wistar albino rats were used in this study. Following exposure to methyl parathion for 3 months, the liver, the brain, and the kidney tissues were removed from the rats. The free and protein-bound SH contents were determined in these tissues. In addition, plasma lactate dehydrogenase levels were determined. Our results showed that methyl parathion exposure significantly lowers the free and protein-bound SH levels in rat tissues. However, lactate dehydrogenase activity in the blood plasma did not display any differences compared to the control group. The free SH concentrations in the control rat liver, brain, and kidney tissues were 3.78 +/- 0.1 mu mol/100 mg tissue, 1.56 +/- 0.08 mu mol/100 mg tissue, and 2.16 +/- 0.08 mu mol/100 mg tissue, respectively, whereas the free SH concentrations in rats exposed to methyl parathion were determined as 0.536 +/- 0.1 mu mol/100 mg tissue in the liver, 1.06 +/- 0.1 mu mol/100 mg tissue in the brain, and 0.108 +/- 0.03 mu mol/100 mg tissue in the kidney. The protein-bound SH concentrations in the liver and in the kidney in rats exposed to methyl parathion displayed a significant decrease also. However, the protein-bound SH level in the brain did not change significantly. These results indicate that methyl parathion exposure partially depletes the free and protein-bound SH levels. Thus, it was concluded that methyl parathion toxicity may partly result from oxidative stress.en_US
dc.identifier.doi10.1080/15376520600616800
dc.identifier.endpage352en_US
dc.identifier.issn1537-6516
dc.identifier.issn1537-6524
dc.identifier.issue7en_US
dc.identifier.pmid20021006en_US
dc.identifier.scopus2-s2.0-33746121921en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage347en_US
dc.identifier.urihttps://doi.org/10.1080/15376520600616800
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10168
dc.identifier.volume16en_US
dc.identifier.wosWOS:000238990700001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofToxicology Mechanisms and Methodsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectfree and protein-bound SHen_US
dc.subjectmethyl parathionen_US
dc.subjectoxidative stressen_US
dc.subjectrat tissuesen_US
dc.titleMethyl parathion-induced changes in free and protein-bound SH levels in rat tissuesen_US
dc.typeArticleen_US

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