Increased QT dispersion in sickle cell disease

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dc.authoridDUMAN, Taskin/0000-0002-6552-4193
dc.contributor.authorAkgul, Ferit
dc.contributor.authorSeyfeli, Ergun
dc.contributor.authorMelek, Ismet
dc.contributor.authorDuman, Taskin
dc.contributor.authorSeydaliyeva, Tunzale
dc.contributor.authorGali, Edip
dc.contributor.authorYalcin, Fatih
dc.date.accessioned2024-09-18T20:55:33Z
dc.date.available2024-09-18T20:55:33Z
dc.date.issued2007
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: QT dispersion has been proposed to be a predictor of adverse outcomes in a variety of cardiac disease states. The objective of this study was to examine QT dispersion in patients with sickle cell disease (SCD) and to assess the effect of pulmonary hypertension (PHT) on QT dispersion. Methods: We performed Doppler echocardiographic assessments of pulmonary artery systolic pressure in 73 (mean age 18.5 +/- 8.0 years) steady-state SCD patients and 25 (mean age 19.6 +/- 7.2 years) healthy subjects. Resting 12-lead electrocardiogram was recorded and QT dispersion was calculated as the difference between maximum and minimum QT intervals. Bazett's formula was used to obtain a rate-corrected value of the QT interval (QTc). Results: Maximum QTc, minimum QTc and QTc dispersion were significantly increased in SCD patients compared to the control subjects (p < 0.0001, p < 0.05, p < 0.0001, respectively). Among SCD patients, patients with PHT had higher maximum QTc and QTc dispersion than patients without PHT (p < 0.0001). However, minimum QTc showed no significant differences between the two patient groups. Conclusion: QTc dispersion is significantly increased in SCD patients, especially those with PHT indicating regional inhomogeneity of ventricular repolarization. Copyright (c) 2007 S. Karger AG, Basel.en_US
dc.identifier.doi10.1159/000100929
dc.identifier.endpage6en_US
dc.identifier.issn0001-5792
dc.identifier.issn1421-9662
dc.identifier.issue1en_US
dc.identifier.pmid17374947en_US
dc.identifier.scopus2-s2.0-34347351317en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1159/000100929
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11914
dc.identifier.volume118en_US
dc.identifier.wosWOS:000246593100001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofActa Haematologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectpulmonary hypertensionen_US
dc.subjectQT dispersionen_US
dc.subjectsickle cell diseaseen_US
dc.subjectventricular repolarizationen_US
dc.titleIncreased QT dispersion in sickle cell diseaseen_US
dc.typeArticleen_US

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