Use of automated quantitative pupillometric evaluation for monitoring the severity of diabetic retinopathy

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dc.authoridCITIRIK, Mehmet/0000-0002-0558-5576
dc.authoridTEKIN, KEMAL/0000-0002-7461-6129
dc.contributor.authorCankurtaran, Veysel
dc.contributor.authorIlhan, Cagri
dc.contributor.authorTekin, Kemal
dc.contributor.authorCitirik, Mehmet
dc.contributor.authorDirican, Emre
dc.contributor.authorGurkan, Eren
dc.date.accessioned2024-09-18T20:15:10Z
dc.date.available2024-09-18T20:15:10Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPurpose: We aimed to evaluate the use of automated quantitative static and dynamic pupillometry in screening patients with type 2 diabetes mellitus and different stages of diabetic retinopathy. Method: 155 patients with type 2 diabetes mellitus (diabetes mellitus group) were included in this study and another 145 age- and sex-matched healthy individuals to serve as the control group. The diabetes mellitus group was divided into three subgroups: diabetes mellitus without diabetic retinopathy (No-diabetic retinopathy), nonproliferative diabetic retinopathy, and proliferative diabetic retinopathy. Static and dynamic pupillometry were performed using a rotating Scheimpflug camera with a topography-based system. Results: In terms of pupil diameter in both static and dynamic pupillometry (p <0.05), statistically significant differences were observed between the diabetes mellitus and control groups and also between the subgroups No-diabetic retinopathy, nonproliferative diabetic retinopathy, and proliferative diabetic retinopathy subgroups. But it was noted that No-diabetic retinopathy and nonproliferative diabetic retinopathy groups have showed similarities in the findings derived from static pupillometry under mesopic and photopic conditions. The two groups also appeared similar at all points during the dynamic pupillometry (p>0.05). However, it could be concluded that the proliferative diabetic retinopathy group was significantly different from the rest of the subgroups, No-diabetic retinopathy and nonproliferative diabetic retinopathy groups, in terms of all the static pupillometry measurements (p<0.05). The average speed of dilation was also significantly different between the diabetes mellitus and control groups and among the diabetes mellitus subgroups (p<0.001). While weak to moderate significant correlations were found between all pupil diameters in static and dynamic pupillometry with the duration of diabetes mellitus (p<0.05 for all), the HbAlc values showed no statistically significant correlations with any of the investigated static and dynamic pupil diameters (p>0.05 for all). Conclusion: This study revealed that the measurements derived from automated pupillometry are altered in patients with type 2 diabetes mellitus. The presence of nonproliferative diabetic retinopathy does not have a negative effect on pupillometry findings, but with proliferative diabetic retinopathy, significant alterations were observed. These results suggest that using automated quantitative pupillometry may be useful in verifying the severity of diabetic retinopathy.en_US
dc.identifier.doi10.5935/0004-2749.20210007
dc.identifier.endpage44en_US
dc.identifier.issn0004-2749
dc.identifier.issn1678-2925
dc.identifier.issue1en_US
dc.identifier.pmid33470340en_US
dc.identifier.scopus2-s2.0-85100228675en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage37en_US
dc.identifier.urihttps://doi.org/10.5935/0004-2749.20210007
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9491
dc.identifier.volume84en_US
dc.identifier.wosWOS:000609259300007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherConsel Brasil Oftalmologiaen_US
dc.relation.ispartofArquivos Brasileiros De Oftalmologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDiabetic retinopathyen_US
dc.subjectDiabetes mellitusen_US
dc.subjectDiagnostic techniques, ophthalmologicalen_US
dc.subjectPupilen_US
dc.subjectReflex, pupillaryen_US
dc.titleUse of automated quantitative pupillometric evaluation for monitoring the severity of diabetic retinopathyen_US
dc.typeArticleen_US

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