Effects of Smoking on Central Corneal Thickness and the Corneal Endothelial Cell Layer in Otherwise Healthy Subjects

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dc.contributor.authorIlhan, Nilufer
dc.contributor.authorIlhan, Ozgur
dc.contributor.authorCoskun, Mesut
dc.contributor.authorDaglioglu, Mutlu C.
dc.contributor.authorTuzcu, Esra Ayhan
dc.contributor.authorKahraman, Hilal
dc.contributor.authorKeskin, Ugurcan
dc.date.accessioned2024-09-18T20:13:21Z
dc.date.available2024-09-18T20:13:21Z
dc.date.issued2016
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjectives:The effects of smoking on central corneal thickness (CCT), corneal endothelial cell density (ECD), and morphology were evaluated in otherwise healthy subjects.Methods:The study included 103 current smokers and 106 healthy nonsmoking subjects without any eye disease apart from refractive errors. Endothelial cell density, percentage of hexagonality, and coefficient of variation (CV) in cell size were measured using noncontact specular microscopy. Central corneal thickness was measured by ultrasound pachymetry.Results:The mean age of participants in the nonsmoker group was 31.4 5.1 years (18-60) and 33.0 +/- 9.1 years (18-58) in the current smoker group. The mean CCT value was 523.7 +/- 34 m in the nonsmoker group and 518.5 +/- 37 m in the smoker group. The mean ECD, CV, and percentage of hexagonality values were 2,881 +/- 293.7 cells per square millimeter, 32.5 +/- 6%, and 56.6 +/- 11% in the nonsmoker group, and 2,681 +/- 323.9 cells per square millimeter, 33.4 +/- 5%, and 55.5 +/- 10% in the smoker group, respectively. Although there was no difference between the groups in terms of CCT, CV, and percentage of hexagonality values, a significant difference was determined in the case of ECD values (P<0.001). The smoker group comprised 67 light smokers (65.0%) and 36 (35.0%) heavy smokers. Between these groups, there was no statistically significant difference in the mean values of CCT, ECD, CV, and the percentage of hexagonality.Conclusions:Although cigarette smoking has no effect on cell polymorphism and polymegethism, the results suggest that smoking reduces endothelial cell count.en_US
dc.identifier.doi10.1097/ICL.0000000000000212
dc.identifier.endpage307en_US
dc.identifier.issn1542-2321
dc.identifier.issn1542-233X
dc.identifier.issue5en_US
dc.identifier.pmid26618903en_US
dc.identifier.scopus2-s2.0-84949032967en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage303en_US
dc.identifier.urihttps://doi.org/10.1097/ICL.0000000000000212
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9117
dc.identifier.volume42en_US
dc.identifier.wosWOS:000384001400007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofEye & Contact Lens-Science and Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCorneal endothelial cell lossen_US
dc.subjectCigarette smokingen_US
dc.subjectSpecular microscopyen_US
dc.subjectCorneal thickness measurementen_US
dc.titleEffects of Smoking on Central Corneal Thickness and the Corneal Endothelial Cell Layer in Otherwise Healthy Subjectsen_US
dc.typeArticleen_US

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