Macrophage migration inhibitory factor in patients with vitiligo and relationship between duration and clinical type of disease

Basit Öğe Kaydı
dc.contributor.authorSerarslan, G.
dc.contributor.authorYonden, Z.
dc.contributor.authorSogut, S.
dc.contributor.authorSavas, N.
dc.contributor.authorCelik, E.
dc.contributor.authorArpaci, A.
dc.date.accessioned2024-09-18T21:05:15Z
dc.date.available2024-09-18T21:05:15Z
dc.date.issued2010
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground. Vitiligo is a disorder of pigmentation characterized by the presence of depigmented skin macules. Cellular immunity is known to have a role in the pathogenesis of vitiligo. Macrophage migration inhibitory factor (MIF) is a potent activator of macrophages and is considered to play an important role in cell-mediated immunity. Aims. To determine serum level of MIF in patients with vitiligo and compare with healthy controls. We also aimed to determine whether there is a relationship between MIF levels and the disease duration, clinical vitiligo and involved body surface area (BSA) in patients with vitiligo. Methods. The study group comprised 30 patients with vitiligo (14 men, 16 women) and 30 healthy controls, matched for age and gender. Blood samples were taken for MIF analysis. Results. The mean serum level of MIF in patients with vitiligo (40.83 +/- 31.66 pg/mL) was significantly higher than that of the control group (21.00 +/- 6.48 pg/mL) (P = 0.002). There was a positive correlation between disease duration and MIF levels (r = 0.601, P < 0.001). Mean MIF level of patients with acral and acrofacial vitiligo (n = 6) was 48.25 +/- 32.02 pg/mL, and of patients generalized vitiligo (n = 18) was 44.46 +/- 35.25 pg/mL. There was no significant difference between these two groups (P > 0.05). However there was a significant difference in MIF levels between patients with localized (20.41 +/- 5.23, n = 5) and acral-acrofacial (P = 0.02) vitiligo and those with generalized (P = 0.006) vitiligo. There was no relationship between BSA and MIF levels. Conclusions. Mean serum MIF level of patients with vitiligo was higher than that of controls, indicating that MIF has a role in the pathogenesis of vitiligo.en_US
dc.identifier.doi10.1111/j.1365-2230.2009.03617.x
dc.identifier.endpage490en_US
dc.identifier.issn0307-6938
dc.identifier.issn1365-2230
dc.identifier.issue5en_US
dc.identifier.pmid19874371en_US
dc.identifier.scopus2-s2.0-77953355781en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage487en_US
dc.identifier.urihttps://doi.org/10.1111/j.1365-2230.2009.03617.x
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13475
dc.identifier.volume35en_US
dc.identifier.wosWOS:000278564200007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofClinical and Experimental Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFactor Mifen_US
dc.subjectGeneticsen_US
dc.titleMacrophage migration inhibitory factor in patients with vitiligo and relationship between duration and clinical type of diseaseen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ N/A ]
İsim:
Tam Metin / Full Text
Boyut:
101.24 KB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu