Is the relationship between periodontitis and hyperlipidemia mediated by lipoprotein-associated inflammatory mediators?

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dc.authoridtozum bulut, memduha/0000-0001-8105-9482
dc.contributor.authorFentoglu, Ozlem
dc.contributor.authorBulut, Memduha Tozum
dc.contributor.authorDogan, Burak
dc.contributor.authorKirzioglu, Fatma Yesim
dc.contributor.authorDogan, Esra Sinem Kemer
dc.date.accessioned2024-09-18T20:27:55Z
dc.date.available2024-09-18T20:27:55Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPurpose: The aim of this study was to evaluate the serum levels of oxidized low-density lipoprotein (oxLDL), anti-oxLDL, and myeloperoxidase (MPO) in hyperlipidemic patients with periodontal disease. Methods: This study included 123 patients with hyperlipidemia categorized based on metabolic control as mild to moderate (H1) (n=66) or poor (H2) (n=57), as well as systemically healthy controls (C) (n=68). Serum levels of lipids, oxLDL, anti-oxLDL, and MPO were evaluated, along with clinical periodontal parameters. Results: The percentage of bleeding on probing (BOP%) and the clinical attachment level were significantly higher in the H2 group than in the C group. Patients with hyperlipidemia had a relatively high risk of developing periodontal disease. The oxLDL and anti-oxLDL levels were higher in H2 patients with periodontitis than in the control or H1 patients with periodontitis. In the H1 and H2 groups, the ratio of total cholesterol to high-density lipoprotein was significantly correlated with gingival index, BOP%, and oxLDL levels. Conclusions: Our findings indicate that the lipoprotein-associated inflammatory mediators of oxLDL, anti-oxLDL, and MPO may play an important role in the relationship between periodontal disease and hyperlipidemia. Conclusions: Our findings indicate that the lipoprotein-associated inflammatory mediators of oxLDL, anti-oxLDL, and MPO may play an important role in the relationship between periodontal disease and hyperlipidemia.en_US
dc.description.sponsorshipTUBITAK [107S056]en_US
dc.description.sponsorshipThis research was financially supported by TUBITAK (project number: 107S056).en_US
dc.identifier.doi10.5051/jpis.2020.50.3.135
dc.identifier.endpage145en_US
dc.identifier.issn2093-2278
dc.identifier.issn2093-2286
dc.identifier.issue3en_US
dc.identifier.pmid32617179en_US
dc.identifier.scopus2-s2.0-85087572450en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage135en_US
dc.identifier.urihttps://doi.org/10.5051/jpis.2020.50.3.135
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10604
dc.identifier.volume50en_US
dc.identifier.wosWOS:000544048700002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKorean Acad Periodontologyen_US
dc.relation.ispartofJournal of Periodontal and Implant Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHyperlipidemiasen_US
dc.subjectOxidized low density lipoproteinen_US
dc.subjectPeriodontal diseasesen_US
dc.subjectPeroxidaseen_US
dc.titleIs the relationship between periodontitis and hyperlipidemia mediated by lipoprotein-associated inflammatory mediators?en_US
dc.typeArticleen_US

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