Prothrombin Time, Activated Thromboplastin Time, Fibrinogen and D-Dimer Levels and von-Willebrand Activity of Patients with Sheehan's Syndrome and the Effect of Hormone Replacement Therapy on These Factors

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dc.contributor.authorPasa, Semir
dc.contributor.authorAltintas, Abdullah
dc.contributor.authorTumer, Cemil
dc.contributor.authorDemircin, Mustafa
dc.contributor.authorCil, Timucin
dc.contributor.authorBayan, Kadim
dc.contributor.authorDanis, Ramazan
dc.date.accessioned2024-09-18T20:04:35Z
dc.date.available2024-09-18T20:04:35Z
dc.date.issued2010
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIncreased mortality due to atherosclerotic cardiovascular disease has been described in adult patients with hypopituitarism, although the precise underlying mechanisms remain undetermined. Various abnormalities of coagulation and fibrinolysis occur in patients with thyroid diseases. Conversely, there are conflicting reports concerning the effects of growth hormone replacement on coagulation and fibrinolytic pathways in hypopituitary adults, and there is no existing data on the effects of hypocortisolism on thrombotic and fibrinolytic systems. The same controversial data were also obtained in studies which evaluate the effects of estrogen replacement therapy on cardiovascular events in post-menopausal women. The aim of this study was to investigate the effects of Sheehan's syndrome (SS), which is a common cause of hypopituitarism, on haemostatic factors and to assess the effects of L-thyroxin, prednisolone and conjugated estrogen / medroxyprogesterone acetate replacement on these factors. Prothrombin time (PT), activated thromboplastin time (aPTT), fibrinogen and D-dimer levels, and von-Willebrand factor (vWF) activity were compared among 32 patients with SS and 35 control subjects (CS) with similar age. A shorter PT and aPTT, higher fibrinogen and d-dimer levels, and similar vWF activity were determined in patients with SS as compared with CS. In addition, it was determined that hormone replacement treatment did not have a significant effect on coagulation parameters except the fibrinogen and d-dimer levels.en_US
dc.identifier.endpage219en_US
dc.identifier.issn1306-133X
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-78651445667en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage212en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8261
dc.identifier.volume20en_US
dc.identifier.wosWOS:000285678300003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAkad Doktorlar Yayinevien_US
dc.relation.ispartofUhod-Uluslararasi Hematoloji-Onkoloji Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBlood coagulationen_US
dc.subjectHemostasisen_US
dc.subjectSheehan's syndromeen_US
dc.subjectHypopituitarismen_US
dc.titleProthrombin Time, Activated Thromboplastin Time, Fibrinogen and D-Dimer Levels and von-Willebrand Activity of Patients with Sheehan's Syndrome and the Effect of Hormone Replacement Therapy on These Factorsen_US
dc.typeArticleen_US

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