Determination of temporal changes in hepatic drug-oxidizing capacity using plasma metabolite/caffeine ratios in non-pregnant and pregnant goats

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dc.authoridCorum, Orhan/0000-0003-3168-2510
dc.authoridUney, Kamil/0000-0002-8674-4873
dc.authoridALTAN, Feray/0000-0002-9017-763X
dc.contributor.authorAltan, Feray
dc.contributor.authorCizmeci, Sakine Ulkum
dc.contributor.authorKose, Ayse Merve
dc.contributor.authorCorum, Orhan
dc.contributor.authorUney, Kamil
dc.date.accessioned2024-09-18T20:06:21Z
dc.date.available2024-09-18T20:06:21Z
dc.date.issued2024
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractCaffeine (CF) is a metabolic probe drug used in the determination of the hepatic drug-oxidizing capacity. The aim of this study was to investigate temporal changes in the hepatic drug-oxidizing capacity using plasma metabolite/CF ratios in non-pregnant goats (n = 11) and pregnant goats (n = 23). CF (5 mg/kg, intravenous) was administered in six periods (Period 1-6) with 45 days between two periods. The plasma levels of CF and its metabolites, theophylline (TP), theobromine (TB) and paraxanthine (PX), were determined by HPLC-UV. To evaluate hepatic drug-oxidizing capacity in terms of enzymes that play a role in CF metabolism, the plasma metabolic ratios including TB/CF, PX/CF, TP/CF and TB + PX + TP/CF were determined at 10 h following CF administration. Plasma metabolite/CF ratios were similar between non-pregnant and pregnant goats. However, plasma metabolite/CF ratios in Period 3 (45 days in pregnant goats) were significantly higher than those other periods in both pregnant and non-pregnant goats. The effect of pregnancy may not be observed on drugs that are substrates of enzymes involved in CF metabolism in goats.en_US
dc.identifier.doi10.1111/jvp.13401
dc.identifier.endpage35en_US
dc.identifier.issn0140-7783
dc.identifier.issn1365-2885
dc.identifier.issue1en_US
dc.identifier.pmid37435998en_US
dc.identifier.scopus2-s2.0-85164817140en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage28en_US
dc.identifier.urihttps://doi.org/10.1111/jvp.13401
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8481
dc.identifier.volume47en_US
dc.identifier.wosWOS:001028899700001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Veterinary Pharmacology and Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcaffeineen_US
dc.subjectgoatsen_US
dc.subjecthepatic drug-oxidizing capacityen_US
dc.subjectpregnancyen_US
dc.titleDetermination of temporal changes in hepatic drug-oxidizing capacity using plasma metabolite/caffeine ratios in non-pregnant and pregnant goatsen_US
dc.typeArticleen_US

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