Unlocking nature's potential: anticancer potential of Helichrysum sanguineum (L.) Kostel on breast cancer cells and its chemical composition

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dc.authoridYabalak, Erdal/0000-0002-4009-4174
dc.authoridBAHADIRLI, NADIRE PELIN/0000-0001-7321-5377
dc.contributor.authorYabalak, Erdal
dc.contributor.authorBahadirli, Nadire Pelin
dc.contributor.authorYetkin, Derya
dc.contributor.authorYaldiz, Fadile Defne
dc.contributor.authorTurkseven, Cagatay Han
dc.date.accessioned2024-09-18T20:26:38Z
dc.date.available2024-09-18T20:26:38Z
dc.date.issued2024
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractHelichrysum sanguineum (L.) Kostel (H. sanguineum), a member of the Asteraceae family, has been traditionally employed for various medicinal purposes owing to its rich phytochemical composition. This study investigates the anticancer properties of various extracts of H. sanguineum (ethanol, acetonitrile, hexane, and chloroform) against breast cancer cells, shedding light on its chemical constituents and their potential therapeutic effects. In vitro assays demonstrate the profound inhibitory effects of H. sanguineum extract on human fibroblast and breast cancer cells. Furthermore, we elucidate the underlying mechanisms of action, revealing its ability to induce apoptosis and cell cycle arrest in breast cancer cells. The cytotoxicity and apoptosis outcomes in breast cancer cells varied across different extracts, yet no adverse effects were observed on healthy cells at equivalent concentrations. Furthermore, all extracts initially promoted breast cancer cell proliferation, with the chloroform extract notably reducing cancer cell proliferation even at low concentrations. GC-MS analysis identifies the major chemical constituents of the extract, including flavonoids, terpenoids, and phenolic compounds, which likely contribute to its anticancer activity. Our findings highlight the potential of H. sanguineum extract as a natural agent for breast cancer treatment and the need for further exploration of its mechanisms and clinical applications.en_US
dc.identifier.doi10.1080/09603123.2024.2360548
dc.identifier.issn0960-3123
dc.identifier.issn1369-1619
dc.identifier.pmid38817209en_US
dc.identifier.scopus2-s2.0-85194876562en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1080/09603123.2024.2360548
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10450
dc.identifier.wosWOS:001236469100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofInternational Journal of Environmental Health Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHelichrysum sanguineumen_US
dc.subjectfibroblasten_US
dc.subjectbreasten_US
dc.subjectcanceren_US
dc.subjectchemical compositionen_US
dc.titleUnlocking nature's potential: anticancer potential of Helichrysum sanguineum (L.) Kostel on breast cancer cells and its chemical compositionen_US
dc.typeArticleen_US

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