Investigation of potential protective effects of Betanin on experimental Monosodium Glutamate-induced toxicity in elderly rats

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dc.authoridogut, serdal/0000-0001-8863-7249
dc.authoridBaytar, Gurkan/0000-0003-1606-2938
dc.contributor.authorBaytar, Gurkan
dc.contributor.authorKutlu, Tuncer
dc.contributor.authorOgut, Serdal
dc.date.accessioned2024-09-18T20:32:56Z
dc.date.available2024-09-18T20:32:56Z
dc.date.issued2024
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThis study was conducted to investigate the protective effects of Betanin active ingredient in red beetroot plant ( Beta vulgaris ) in elderly rats exposed to chronic toxicity of monosodium glutamate (MSG). A total of 48 elderly rats were randomly divided into 4 different groups. At the end of the 28-day study, the rats were sacrificed under deep anesthesia. Total antioxidant capacity (TAC), total oxidant capacity (TOC), paraoxonase (PON), thiol, malondialdehyde (MDA), and nitric oxide (NO) levels were investigated in rat blood serum using the spectrophotometric method. Oxidative Stress Index (OSI) was calculated by dividing TOC by TAC. Total bilirubin was measured with the colorimetric method using an ELISA kit. Liver tissues were stained with hematoxylin-eosin (HE) for histopathological examination. The difference in serum levels of TAC, TOC, OSI, PON, MDA, and thiol was statistically significant between the groups ( P <0.05). The difference in serum levels of NO and total bilirubin was not statistically significant between the groups ( P >0.05). The analysis of histopathological findings revealed uncommon mild hydropic degeneration in the MSG group and almost normal histological appearance in the MSG+Betanin group. This study demonstrated that betanin could increase the antioxidant effect and reduce the histopathological damage caused by MSG.en_US
dc.description.sponsorshipAydin Adnan Menderes University Scientific Research Projects Unit [SBF-20006]en_US
dc.description.sponsorshipThe thesis study was financed by Aydin Adnan Menderes University Scientific Research Projects Unit (BAP No: SBF-20006) . This manuscript is derived from the PhD thesis of the first author, and some of the findings were presented at the scientific meeting (Internat & imath;onal Congress Of Gerontology, Sivas Cumhuriyet University Gerontology Studies Application and Research Center 1. International Congress Of Gerontology, 18-20 March 2022) .en_US
dc.identifier.doi10.52973/rcfcv-e34347
dc.identifier.issn0798-2259
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85192981158en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.urihttps://doi.org/10.52973/rcfcv-e34347
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11222
dc.identifier.volume34en_US
dc.identifier.wosWOS:001216661700006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherUniv Zulia, Facultad Ciencias Veterinariasen_US
dc.relation.ispartofRevista Cientifica-Facultad De Ciencias Veterinariasen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMonosodium glutamateen_US
dc.subjectaged ratsen_US
dc.subjectbiochemistryen_US
dc.subjectbetaninen_US
dc.subjecthistopathologyen_US
dc.titleInvestigation of potential protective effects of Betanin on experimental Monosodium Glutamate-induced toxicity in elderly ratsen_US
dc.typeArticleen_US

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