The relation of fragmented QRS with tissue Doppler derived parameters in patients with b-thalassaemia major

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dc.authoridSokmen, Erdogan/0000-0002-8170-5912
dc.contributor.authorBuyukkaya, Eyup
dc.contributor.authorKarakas, Mehmet Fatih
dc.contributor.authorKurt, Mustafa
dc.contributor.authorBilen, Perihan
dc.contributor.authorYalcin, Fatih
dc.contributor.authorCelik, Murat
dc.contributor.authorHelvaci, Rami
dc.date.accessioned2024-09-18T21:06:49Z
dc.date.available2024-09-18T21:06:49Z
dc.date.issued2012
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPurpose: The most important complication encountered in patients with b-thalassaemia major is degenerative fibrosis developing as a result of iron accumulation in myocardial tissue. Dysfunction pursues this accumulation. Recently, presence of fragmented QRS (fQRS) in ECG has been regarded as a predictor of myocardial fibrosis. We aimed in our study to investigate the frequency with which fQRS develops in patients with b-thalassaemia major and to disclose the correlation between fQRS frequency and Doppler-derived indices. Methods: The patients with b-thalassaemia major (n=66; mean age: 23 +/- 6 years) and healthy controls (n=30; mean age: 23 +/- 4 years) were included. fQRS pattern was described as presence of RSR' manifested as existence of additional R wave and notching in either R or S waves in ECG recordings. 2D, M-mode, conventional Doppler, tissue Doppler echocardiography parameters were assessed. Mean serum ferritin levels over past 5 years were also calculated. Results: When compared to those in control group, fQRS was more frequent in b-thalassaemia major group, indicating statistical significance (p = 0.001). While E/Em and ferritin level exhibited statistically significant increase in thalassaemia patients with fQRS (p < 0.05), the mean Em and Sm values were found to be significantly low (p < 0.05). Conclusions: fQRS was frequently observed in the patients with b-thalassaemia major, which was of statistical significance. Tissue Doppler-derived diastolic and systolic indices in thalassaemia cases with fQRS showed statistically significant impairment compared to those without fQRS. In conclusion, fQRS may represent a novel noninvasive marker for cardiac involvement in patients with b-thalassaemia major.en_US
dc.identifier.endpageE339en_US
dc.identifier.issn0147-958X
dc.identifier.issn1488-2353
dc.identifier.issue5en_US
dc.identifier.pmid23043715en_US
dc.identifier.scopus2-s2.0-84872030012en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpageE334en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13832
dc.identifier.volume35en_US
dc.identifier.wosWOS:000314227300011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCanadian Soc Clinical Investigationen_US
dc.relation.ispartofClinical and Investigative Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBeta-Thalassemiaen_US
dc.subjectDiastolic Functionen_US
dc.subjectMyocardial Dysfunctionen_US
dc.subjectEchocardiographyen_US
dc.subjectHypertensionen_US
dc.subjectSeverityen_US
dc.titleThe relation of fragmented QRS with tissue Doppler derived parameters in patients with b-thalassaemia majoren_US
dc.typeArticleen_US

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