Gender differences in severity of sickle cell diseases in non-smokers

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dc.contributor.authorHelvaci, Mehmet Rami
dc.contributor.authorAyyildiz, Orhan
dc.contributor.authorGundogdu, Mehmet
dc.date.accessioned2024-09-18T20:02:43Z
dc.date.available2024-09-18T20:02:43Z
dc.date.issued2013
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: To find out gender differences in severity of sickle cell diseases (SCDs) in non-smokers. Methods: Three groups of SCDs patients on the basis of red blood cell (RBC) transfusions were included. Less than 10 units in their lives were kept in Group-1, Ten units of higher in Group-2 and 50 units or higher as the Third Group. Patients with a history of using one pack of cigarettes -year or above were excluded. Results: The study included 269 patients. Mean ages of the groups were similar (28.4, 28.5, and 28.9 years, respectively). Prevalences of cases without any RBC transfusion in their lives were 7.2% and 3.7% in females and males, respectively (p < 0.05). Prevalences of cases without any painful crisis were 13.8% and 6.0% in females and males, respectively (p < 0.001). There was progressive increase according to mean painful crises, clubbing, chronic obstructive pulmonary disease (COPD), leg ulcers, stroke, chronic renal disease (CRD), pulmonary hypertension, and male ratio from the first towards the third groups (p < 0.05, nearly for all). Mean ages of mortal cases were 29.1 and 26.2 years in females and males, respectively (p > 0.05). Conclusion: The higher painful crises per year, digital clubbing, COPD, leg ulcers, stroke, CRD, pulmonary hypertension, and male ratio of the third group, lower male ratio of patients without any RBC transfusion, lower male ratio of patients without any painful crisis, lower mean ages of male SCDs patients with mortality, and longer overall survival of females in the world could not be explained by well known strong atherosclerotic effects of smoking alone, instead it may be explained by the dominant role of male sex in life.en_US
dc.identifier.doi10.12669/pjms.294.3697
dc.identifier.endpage1054en_US
dc.identifier.issn1682-024X
dc.identifier.issue4en_US
dc.identifier.pmid24353686en_US
dc.identifier.scopus2-s2.0-84879835146en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1050en_US
dc.identifier.urihttps://doi.org/10.12669/pjms.294.3697
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7990
dc.identifier.volume29en_US
dc.identifier.wosWOS:000322619000033en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherProfessional Medical Publicationsen_US
dc.relation.ispartofPakistan Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAtherosclerosisen_US
dc.subjectGender differencesen_US
dc.subjectSickle cell diseasesen_US
dc.subjectNon-smokersen_US
dc.titleGender differences in severity of sickle cell diseases in non-smokersen_US
dc.typeArticleen_US

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