Comparison of Quantiferon Test with Tuberculin Skin Test for the Detection of Tuberculosis Infection in Children

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dc.authoridonur, hatice/0000-0002-1218-0745
dc.contributor.authorOnur, Hatice
dc.contributor.authorHatipoglu, Sami
dc.contributor.authorArica, Vefik
dc.contributor.authorHatipoglu, Nevin
dc.contributor.authorArica, Secil Gunher
dc.date.accessioned2024-09-18T21:00:24Z
dc.date.available2024-09-18T21:00:24Z
dc.date.issued2012
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe efficacy of Quantiferon-TB gold test (QFT-GIT) remains to be documented in pediatric population. Tuberculin skin test (TST) is a conventional test available for the diagnosis of latent tuberculosis infection (LTBI). We aimed to investigate the concordance between QFT-GIT and TST in children with and without tuberculosis infection. Ninety-seven patients, aged 3 months-14 years, admitted to pediatric outpatient clinics of Dr. Sadi Konuk Training Hospital BakA +/- rkoy, Turkey between March 2008 and April 2009 were recruited. Demographic features, TST results, history of exposure to active tuberculosis (TB), chest X-ray findings, clinical history, presence of Bacillus Calmette Guerin (BCG) vaccination scar were recorded. Patients were categorized into four groups namely, active TB, LTBI, no TB and healthy. It was found that BCG scar positivity did not influence QFT-GIT results. There was a statistically significant agreement between QFT-GIT and TST results (kappa = 0.486; p < 0.01). In patients a parts per thousand yen5 years of age, TST positivity and QFT positivity had a significant relationship (p < 0.01). In all patient groups, sensitivity and specificity was 65.85 % and 82.14 %, respectively. In active TB group, TST and QFT-GIT results demonstrated significant agreement ratio of 40.8 % (kappa = 0.364; p < 0.01). Sensitivity and specificity was 100 % and 30 %, respectively. Utilization of QFT-GIT in the diagnosis of LTBI reduces false-positive results and prevents unnecessary treatment with INH and its adverse effects.en_US
dc.identifier.doi10.1007/s10753-012-9466-1
dc.identifier.endpage1524en_US
dc.identifier.issn0360-3997
dc.identifier.issn1573-2576
dc.identifier.issue4en_US
dc.identifier.pmid22535495en_US
dc.identifier.scopus2-s2.0-84866733064en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1518en_US
dc.identifier.urihttps://doi.org/10.1007/s10753-012-9466-1
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12662
dc.identifier.volume35en_US
dc.identifier.wosWOS:000306547400035en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer/Plenum Publishersen_US
dc.relation.ispartofInflammationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecttuberculosisen_US
dc.subjectquantiferonen_US
dc.subjecttuberculin skin testen_US
dc.subjectBCGen_US
dc.titleComparison of Quantiferon Test with Tuberculin Skin Test for the Detection of Tuberculosis Infection in Childrenen_US
dc.typeArticleen_US

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