TNF-alpha, IL-6, IL-10 and fatty acids in rheumatoid arthritis patients receiving cDMARD and bDMARD therapy

dc.authoridOzkan, Huseyin/0000-0001-5753-8985
dc.authoridCamdeviren, Baran/0000-0003-1508-7869
dc.authoridKacmaz, Filiz/0000-0002-7166-8265
dc.contributor.authorDogan, Serdar
dc.contributor.authorKimyon, Gezmis
dc.contributor.authorOzkan, Huseyin
dc.contributor.authorKacmaz, Filiz
dc.contributor.authorCamdeviren, Baran
dc.contributor.authorKaraaslan, Irem
dc.date.accessioned2024-09-18T20:04:21Z
dc.date.available2024-09-18T20:04:21Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective The present study aimed to examine the effects of cDMARD and bDMARD therapy on both gene expressions and protein levels of TNF-alpha, IL-6, IL-10 and fatty acid levels in patients with RA. Method Plasma TNF-alpha, IL-6, and IL-10 levels were examined by the ELISA method, while TNF-alpha, IL-6, and IL-10 gene expression levels were examined by RT-qPCR, and fatty acid levels were examined by GC/MS. Results IL-10 gene expression levels significantly increased in RA patients receiving cDMARD treatment compared to those of the control group. Also, eicosadienoic acid, myristoleic acid and capric acid levels were significantly lower in the patient groups compared to those in the control group. Conclusion The drugs used in the treatment of RA had no effect on the fatty acid levels whereas had effects on the mRNA and protein levels of the target cytokines.en_US
dc.identifier.doi10.1007/s10067-022-06180-5
dc.identifier.endpage2349en_US
dc.identifier.issn0770-3198
dc.identifier.issn1434-9949
dc.identifier.issue8en_US
dc.identifier.pmid35467309en_US
dc.identifier.scopus2-s2.0-85128856426en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2341en_US
dc.identifier.urihttps://doi.org/10.1007/s10067-022-06180-5
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8096
dc.identifier.volume41en_US
dc.identifier.wosWOS:000787112600001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer London Ltden_US
dc.relation.ispartofClinical Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbDMARDen_US
dc.subjectcDMARDen_US
dc.subjectFree fatty aciden_US
dc.subjectIL-10en_US
dc.subjectRheumatoid arthritisen_US
dc.titleTNF-alpha, IL-6, IL-10 and fatty acids in rheumatoid arthritis patients receiving cDMARD and bDMARD therapyen_US
dc.typeArticleen_US

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