A comparison of fucidic acid and cefazoline released from cancellous human bone

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dc.contributor.authorDogramaci, Yunus
dc.contributor.authorKalacı, Aydıner
dc.contributor.authorOzer, Burcin
dc.contributor.authorOzden, Raif
dc.contributor.authorHapa, Onur
dc.contributor.authorYanat, Ahmet Nedim
dc.date.accessioned2024-09-18T20:26:51Z
dc.date.available2024-09-18T20:26:51Z
dc.date.issued2011
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThis study was designed to determine the antibacterial activity of fucidic acid or cefazoline in cancellous bone obtained from patients undergoing total knee replacement. Thirty samples of cancellous bone were obtained from patients undergoing total joint arthroplasty for primary osteoarthritis of knee joints. The prophylactic antibiotics were infused to the subjects an hour before the operation. In the first group (15 samples) fucidic acid (500 mg intravenous) was used as a prophylactic antibiotics and 1st generation of cephalosporin were used in the second group (15 samples) as the prophylaxis. Same strains of Staphyloccocus aureus were used to assess the antibiotic activity using the disc diffusion technique after 1, 3, 7, 10, 14, 18, 21 and 28 days. The antibiotic efficacy was defined as an inhibition zone diameter of 10 mm. Inhibition zone diameters were significantly higher in fusidic acid than cefazoline specimens on the first, third and 14th day after the incubation (P<0.05). No statistically significant difference was found in the inhibition zone diameter at the seventh, 18th and 21st days. Evaluation of inhibition zone diameters showed that samples obtained from the first group (fucidic acid) had a longer duration of antibiotic release than that of second group (cefazolin). Fucidic acid shows a higher release and a longer antibacterial activity when used as a prophylactic antibiotic compared to cefazolin.en_US
dc.identifier.doi10.5897/AJMR11.879
dc.identifier.endpage5229en_US
dc.identifier.issn1996-0808
dc.identifier.issue29en_US
dc.identifier.startpage5226en_US
dc.identifier.urihttps://doi.org/10.5897/AJMR11.879
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10565
dc.identifier.volume5en_US
dc.identifier.wosWOS:000298923600013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherAcademic Journalsen_US
dc.relation.ispartofAfrican Journal of Microbiology Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHuman cancellous boneen_US
dc.subjectpreoperative prophylaxisen_US
dc.subjectfucidic aciden_US
dc.subjectcefazolineen_US
dc.titleA comparison of fucidic acid and cefazoline released from cancellous human boneen_US
dc.typeArticleen_US

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