Systemic side effects of locally used oxymetazoline

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dc.authoridSefil, Fatih/0000-0001-5534-7448
dc.authoridDokuyucu, Recep/0000-0001-7881-8871
dc.authoridDokuyucu, Recep/0000-0001-6837-3477
dc.contributor.authorDokuyucu, Recep
dc.contributor.authorGokce, Hasan
dc.contributor.authorSahan, Mustafa
dc.contributor.authorSefil, Fatih
dc.contributor.authorTas, Zeynel Abidin
dc.contributor.authorTutuk, Okan
dc.contributor.authorOzturk, Atakan
dc.date.accessioned2024-09-18T20:33:07Z
dc.date.available2024-09-18T20:33:07Z
dc.date.issued2015
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjectives: The object of the study is to experimentally investigate the possible systemic side effects of Oxymetazoline including its nasal spray which has been in use for a long time both by the physicians and patients. There is no study in the literature to address the damages of oxymetazoline on the end organ. Materials and methods: The study conducted on 2 groups of rat. Group 1 (n = 8): Control; and Group 2 (n = 8): Oxymetazoline. During 4 week, the control group was applied with 2 drops of saline water on each nasal cavity 3 times a day and the other group was applied with 2 drops of oxymetazoline HCl 3 times a day. At the end of experiment, samples from mandible, parotid and tails of the rats were taken in 10% formalin for histopathological investigations. Results: In histopathological experiments, when compared with the control group, the oxymetazoline group showed significant increase in many of the histopathological parameters (ischemic changes: P = 0.0001; congestion: P = 0.0006; arterial thrombosis: P = Ns; PNL accumulations: P = 0.001; necrosis: P = 0.0001; and ulceration: P = 0.014). The results of histopathologic tests on the samples taken from mandible and parotid gland, in comparison with the control group, showed no significant increase (focal inflammation: P = Ns; and lymphocyte aggregation: P = Ns). Conclusion: Due to the damage that the long-term use of nasal spray including oxymetazoline, it may cause injury on the end organ, which we revealed in our histopathological experiments. We believe that it's essential for the physicians to provide information on the side effects of the medicine to their patients who use for a long term.en_US
dc.identifier.endpage2678en_US
dc.identifier.issn1940-5901
dc.identifier.issue2en_US
dc.identifier.pmid25932218en_US
dc.identifier.scopus2-s2.0-84926395657en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage2674en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11315
dc.identifier.volume8en_US
dc.identifier.wosWOS:000355306000134en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherE-Century Publishing Corpen_US
dc.relation.ispartofInternational Journal of Clinical and Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNasal sprayen_US
dc.subjectoxymetazolineen_US
dc.subjectsystemic side effectsen_US
dc.subjectend-organ injuryen_US
dc.titleSystemic side effects of locally used oxymetazolineen_US
dc.typeArticleen_US

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