MMP7 and YKL-40 expressions in endometrial endometrioid carcinomas

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dc.contributor.authorTas, Z. A.
dc.contributor.authorOzgur, T.
dc.contributor.authorYaldiz, M.
dc.contributor.authorDolapcioglu, K.
dc.date.accessioned2024-09-18T20:16:52Z
dc.date.available2024-09-18T20:16:52Z
dc.date.issued2019
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPurpose of investigation: The expressions of YKL-40, MMP-7 and their relations with prognostic factors in endometrioid endometrial carcinomas (EEC) were investigated. Materials and Methods: Paraffin blocks of 50 patients diagnosed with EEC, 27 patients with endometrial hyperplasia, and 26 patients with normal cyclic endometrium were determined and the immunohistochemical staining (IHS) results of MMP-7 and YKL-40 antibodies were obtained. These results were compared with prognostic parameters with statistical evaluation. Results: Score 1 immunostaining was observed in 13 (26%), score 2 in 12 (24%), score 3 in 9 (18%), score 4 in 5 (10%) with MMP-7 in EEC. There was no MMP-7 expression in 9 (% 18) cases in carcinoma group. There was no statistically significant difference in proliferative and secretory phases in normal cycle group (p = 0.527). There was also no statistically significant difference between the non-typical and atypical hyperplasia/EIN cases (p = 0.42). Positive immunostaining was obtained in 15 (58%) of 26 normal cyclic endometrium, in 21 (78%) of 27 hyperplastic endometrium, in 19 (38%) of 50 EEC with YKL-40. The differences of YKL-40 expressions among all the groups were statistically significant (p = 0.01)). MMP-7 and YKL-40 expressions were compared with clinicopathologic parameters in the carcinoma group and found no statistical significant difference (p > 0.05). Conclusion: The present findings were limited but suggested that MMP-7 and YKL-40 might play a role in tumor progression.en_US
dc.description.sponsorshipMustafa Kemal University, The Department of Scientific Research Projects [14031]en_US
dc.description.sponsorshipThis study was funded by Mustafa Kemal University, The Department of Scientific Research Projects, with grant number 14031.en_US
dc.identifier.doi10.12892/ejgo4515.2019
dc.identifier.endpage129en_US
dc.identifier.issn0392-2936
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85066984136en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage123en_US
dc.identifier.urihttps://doi.org/10.12892/ejgo4515.2019
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9786
dc.identifier.volume40en_US
dc.identifier.wosWOS:000465530900022en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherI R O G Canada, Incen_US
dc.relation.ispartofEuropean Journal of Gynaecological Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEndometrioid endometrial carcinomaen_US
dc.subjectYKL-40en_US
dc.subjectMMP-7en_US
dc.subjectImmunohistochemistryen_US
dc.titleMMP7 and YKL-40 expressions in endometrial endometrioid carcinomasen_US
dc.typeArticleen_US

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