Hypothalamic superoxide dismutase, xanthine oxidase, nitric oxide, and malondialdehyde in rats fed with fish ?-3 fatty acids

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dc.authoridSongur, Ahmet/0000-0002-6683-5495
dc.contributor.authorSongur, A
dc.contributor.authorSarsilmaz, M
dc.contributor.authorSogut, S
dc.contributor.authorOzyurt, B
dc.contributor.authorOzyurt, H
dc.contributor.authorZararsiz, I
dc.contributor.authorTurkoglu, AO
dc.date.accessioned2024-09-18T20:27:56Z
dc.date.available2024-09-18T20:27:56Z
dc.date.issued2004
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPhosphohpids located in the cellular membrane play a critical role in the fluid-mosaic model of membrane structure and membrane function. Evidence is mounting for the role of abnormal phospholipid metabolism in some neuropsychiatric disorders including schizophrenia. As an important essential fatty acid (EFA), omega-3 (omega-3) fatty acid series are found in large amounts in fish oil. The aim of this experimental study was to assess the changes of some of the oxidant and antioxidant parameters in the hypothalamus of rats fed with omega-3 EFA diet (0.4 g/kg/day) for 30 days. Eight control rats and nine rats fed with omega-3 were decapitated under ether anesthesia, and hypothalamus was removed immediately. Malondialdehyde (NIDA) and nitric oxide (NO) levels as well as superoxide dismutase (SOD) and xanthine oxidase (XO) enzyme activities in the hypothalamus were measured. SOD activity was significantly decreased in omega-3 EFA treated group compared to control group (p < 0.014). Tissue NIDA and NO levels were also decreased in omega-3 EFA treated group compared to control rats (p < 0.0001). Xanthine oxidase activity was found to be increased in w-3 EFA treated rats when compared to the control group (p < 0.0001). Taken together, this preliminary animal study provides strong support for a therapeutic effect of omega-3 EFA in some neuropsychiatric disorders in which reactive oxygen species (ROS) are recently accused to be an important physiopathogenetic factor. (C) 2004 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.pnpbp.2004.05.006
dc.identifier.endpage698en_US
dc.identifier.issn0278-5846
dc.identifier.issn1878-4216
dc.identifier.issue4en_US
dc.identifier.pmid15276695en_US
dc.identifier.scopus2-s2.0-3342913098en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage693en_US
dc.identifier.urihttps://doi.org/10.1016/j.pnpbp.2004.05.006
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10624
dc.identifier.volume28en_US
dc.identifier.wosWOS:000223392600011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofProgress in Neuro-Psychopharmacology & Biological Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecthypothalamusen_US
dc.subjectmalondialdehydeen_US
dc.subjectnitric oxideen_US
dc.subjectomega-3 essential fatty acidsen_US
dc.subjectsuperoxide distrimaseen_US
dc.subjectxanthine oxidaseen_US
dc.titleHypothalamic superoxide dismutase, xanthine oxidase, nitric oxide, and malondialdehyde in rats fed with fish ?-3 fatty acidsen_US
dc.typeReview Articleen_US

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