The Protective Effect of Ellagic Acid Against Renal Ischemia-Reperfusion Injury in Male Rats

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dc.contributor.authorBozkurt, Yasar
dc.contributor.authorFirat, Ugur
dc.contributor.authorAtar, Murat
dc.contributor.authorSancaktutar, Ahmet Ali
dc.contributor.authorPembegul, Necmettin
dc.contributor.authorSoylemez, Haluk
dc.contributor.authorYuksel, Hatice
dc.date.accessioned2024-09-18T19:54:37Z
dc.date.available2024-09-18T19:54:37Z
dc.date.issued2012
dc.departmentHatay Mustafa Kemal Ãœniversitesien_US
dc.description.abstractThe aim of this study was to evaluate the possible protective effect of ellagic acid (EA) on rats following renal ischemia reperfusion (I/R) injury. Twenty-four Wistar rats were divided into three groups. Sham group underwent laparotomy then waited for 45 min without ischemia. I/R group were subjected to left renal ischemia for 45 minutes followed by 60 min of reperfusion. I/R+EA group were subjected to the same renal ischemia/reperfusion as the I/R group, were also given 85 mg/kg EA perorally 30 min prior to the ischemia. Malondialdehyde (MDA), total antioxidant capacity (TAC), total oxidant status (TOS), and oxidative stress index (OSI) were determined on the blood samples and kidney tissues. Histopathological analyses were conducted on the kidney tissues. I/R damage significantly increased serum MDA levels in the I/R group when compared with Sham group. Serum TAC level was significantly lower in I/R group than I/R+EA group. A significantly increase on OSI levels and decrease on TAC levels was found in the kidneys in I/R group. In I/R + EA group, EA reversed the negative effects of I/R injury. EA pretreatment was effective in decreasing tubular necrosis score. In conclusion; EA pretreatment ameliorated the oxidative damage and histopathological changes occurring following renal I/R injury.en_US
dc.identifier.endpage828en_US
dc.identifier.issn1300-6045
dc.identifier.issue5en_US
dc.identifier.startpage823en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7825
dc.identifier.volume18en_US
dc.identifier.wosWOS:000307911300018en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherKafkas Univ, Veteriner Fakultesi Dergisien_US
dc.relation.ispartofKafkas Universitesi Veteriner Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidanten_US
dc.subjectEllagic aciden_US
dc.subjectIschemia-reperfusionen_US
dc.subjectRaten_US
dc.subjectKidneyen_US
dc.titleThe Protective Effect of Ellagic Acid Against Renal Ischemia-Reperfusion Injury in Male Ratsen_US
dc.typeArticleen_US

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