Effects of 2,4-D (dichlorophenoxyacetic acid) on blood anti-oxidant oxidant balance and on tissues in lambs

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dc.authoridAytekin, Ismail/0000-0001-6794-5453
dc.contributor.authorAytekin, I.
dc.contributor.authorOnmaz, A. C.
dc.contributor.authorAlp, H.
dc.contributor.authorUlucan, A.
dc.date.accessioned2024-09-18T19:47:57Z
dc.date.available2024-09-18T19:47:57Z
dc.date.issued2010
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIn this study, the effects of the common herbicide 2,4-D (dichlorophenoxyacetic acid) on blood antioxidant / oxidant status and on various organs were investigated in Sakiz crossbred lambs. For that, 6 lambs were poisoned accidentally with the herbicide whereas 6 other healthy animals served as negative controls and plasma MDA and GSH concentrations as well as serum ascorbate, retinol and beta-carotene concentrations were determined by spectrophotometry two days later. In parallel, conventional histological analysis was performed on lungs, liver, kidney and heart front a lamb dead after 2,4-D exposure. Blood antioxidant/oxidant balance was altered due to a significant increase of MDA concentrations coupled to a significant decrease of GSH concentrations in intoxicated lambs compared to controls. Congestive lesions and some haemorrhages were evidenced in lungs and kidneys and cell degeneration associated with lymphocyte infiltrate were observed in liver, kidneys and in heart. These results highly suggest that the herbicide 2.4-D induces an oxidative stress leading to cell destructions and tissue injury.en_US
dc.identifier.endpage287en_US
dc.identifier.issn0035-1555
dc.identifier.issn2258-0646
dc.identifier.issue6en_US
dc.identifier.startpage283en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7245
dc.identifier.volume161en_US
dc.identifier.wosWOS:000280493600006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherEcole Nationale Veterinaire Toulouseen_US
dc.relation.ispartofRevue De Medecine Veterinaireen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject2,4-D (dichlorophenoxyacetic acid)en_US
dc.subjectlambsen_US
dc.subjectglutathioneen_US
dc.subjectmalondialdehydeen_US
dc.subjectoxidative stressen_US
dc.subjectnecrosisen_US
dc.subjecthistopathological analysisen_US
dc.titleEffects of 2,4-D (dichlorophenoxyacetic acid) on blood anti-oxidant oxidant balance and on tissues in lambsen_US
dc.typeArticleen_US

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