Oxidase activity of ceruloplasmin and some acute phase reactant and trace element concentrations in serum of patients with chronic lymphocytic leukemia

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dc.authoridyilmaz, adnan/0000-0003-4842-1173
dc.contributor.authorGundogdu, M.
dc.contributor.authorKaya, H.
dc.contributor.authorGulcin, I.
dc.contributor.authorErdem, F.
dc.contributor.authorCayir, K.
dc.contributor.authorKeles, M.
dc.contributor.authorYilmaz, A.
dc.date.accessioned2024-09-18T21:06:32Z
dc.date.available2024-09-18T21:06:32Z
dc.date.issued2007
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIn the present study, we aimed to investigate the parameters in serum of patients with chronic lymphocytic leukaemia (CLL) and correlate with the cancer stage. The serum concentrations of ceruloplasmin, a-1-acid glycoprotein, albuminumin, transferrin, copper, zinc, manganese, and ceruloplasmin oxidase activity were measured, and compared with those from a healthy control group. The serum from 34 patients with CLL were extracted before chemotherapy. Serum transferrin, allbuminumin and Zinc concentrations were lower in patients with CLL while serum a-1-acid glycoprotein, ceruloplasmin, copper concentrations, and ceruloplasmin oxidase activity were higher in CLL patients when compared with the control group. Although serum manganese concentration was lower in CLL groups than in the control group, the difference was not statistically significant. Serum transferrin concentration was lower in the early stage group compared with the advanced stage. Serum ceruloplasmin level positively correlated with serum ceruloplasmin oxidase activity in patients from the early stage group. Serum ceruloplasmin level positively correlated with serum ceruloplasmin oxidase activity in patients with advanced stage. In conclusion, increased serum ceruloplasmin oxidase activity, ceruloplasmin, a-1-acid glycoprotein, copper levels and decreased transferrin and albuminumin, unchanged manganese levels are associated with CLL and appear to be a consequence of the disease itself.en_US
dc.identifier.doi10.1258/rsmsmj.52.1.24
dc.identifier.endpage27en_US
dc.identifier.issn0036-9330
dc.identifier.issue1en_US
dc.identifier.pmid17373421en_US
dc.identifier.scopus2-s2.0-33947154686en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage24en_US
dc.identifier.urihttps://doi.org/10.1258/rsmsmj.52.1.24
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13681
dc.identifier.volume52en_US
dc.identifier.wosWOS:000244628400006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherScottish Medical Journalen_US
dc.relation.ispartofScottish Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOxidant/Antioxidant Statusen_US
dc.subjectSuperoxide-Dismutaseen_US
dc.subjectAntioxidant Proteinsen_US
dc.subjectLipid-Peroxidationen_US
dc.subjectCancer-Patientsen_US
dc.subjectCarcinomaen_US
dc.subjectCopperen_US
dc.subjectZincen_US
dc.subjectCellen_US
dc.subjectMalondialdehydeen_US
dc.titleOxidase activity of ceruloplasmin and some acute phase reactant and trace element concentrations in serum of patients with chronic lymphocytic leukemiaen_US
dc.typeArticleen_US

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