Prevention of Peri-procedural Myocardial Injury Using a Single High Loading Dose of Rosuvastatin

Basit Öğe Kaydı
dc.contributor.authorCay, Serkan
dc.contributor.authorCagirci, Goksel
dc.contributor.authorSen, Nihat
dc.contributor.authorBalbay, Yucel
dc.contributor.authorDurmaz, Tahir
dc.contributor.authorAydogdu, Sinan
dc.date.accessioned2024-09-18T20:27:58Z
dc.date.available2024-09-18T20:27:58Z
dc.date.issued2010
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractExtensively used lipid-lowering statins have also non-lipid-lowering, pleiotropic effects. Previous studies have demonstrated that a pre-procedural single dose of atorvastatin is associated with reduced peri-procedural myocardial injury. The aim of the present study was to demonstrate the effect of a single high loading dose (40 mg) of rosuvastatin on peri-procedural myocardial injury. Two hundred ninety nine statin-naive patients with stable angina and de novo lesions eligible for PCI were randomized to a rosuvastatin-treatment (n = 153) and to a no-treatment (n = 146) group. A 40 mg loading dose of rosuvastatin was administrated 24 h before the PCI. CK-MB and cTnI levels were measured before and 12 h after the procedure. Baseline characteristics were fairly similar between the two arms. The incidence of a CK-MB and cTnI elevation > 3x ULN in the rosuvastatin group was significantly lower compared to the control group (0.7% vs. 11.0%, p < 0.001 and 10.5% vs. 39.0%, p < 0.001, respectively). Similarly, the incidence of any CK-MB and cTnI elevation > ULN in the rosuvastatin group was significantly lower compared to the control group (10.5% vs. 34.2%, p < 0.001 and 20.9% vs. 61.6%, p < 0.001, respectively). In addition, CK-MB and cTnI values 12 h after the PCI were significantly lower in the rosuvastatin group compared to the control group (20.13 +/- 7.24 U/L vs. 27.02 +/- 18.64 U/L, p < 0.001 and 0.14 +/- 0.34 ng/ml vs. 0.35 +/- 0.40 ng/ml, p < 0.001, respectively). A single high loading dose of rosuvastatin reduces the incidence of peri-procedural myocardial necrosis and infarction effectively.en_US
dc.identifier.doi10.1007/s10557-010-6224-1
dc.identifier.endpage47en_US
dc.identifier.issn0920-3206
dc.identifier.issn1573-7241
dc.identifier.issue1en_US
dc.identifier.pmid20217203en_US
dc.identifier.scopus2-s2.0-77951295359en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage41en_US
dc.identifier.urihttps://doi.org/10.1007/s10557-010-6224-1
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10650
dc.identifier.volume24en_US
dc.identifier.wosWOS:000276709500006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofCardiovascular Drugs and Therapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInfarctionen_US
dc.subjectNecrosisen_US
dc.subjectRosuvastatinen_US
dc.titlePrevention of Peri-procedural Myocardial Injury Using a Single High Loading Dose of Rosuvastatinen_US
dc.typeArticleen_US

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