The Expression of MMP-11 In Benign Meningiomas

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dc.authoridsav, aydin/0000-0002-7326-7801
dc.authoridElmaci, Ilhan/0000-0001-9433-0307
dc.contributor.authorAyan, Erdogan
dc.contributor.authorUyar, Suheyla Bozkurt
dc.contributor.authorCerci, Ajlan
dc.contributor.authorAltas, Murat
dc.contributor.authorBolukbasi, Fatihhan
dc.contributor.authorElmaci, Ilhan
dc.contributor.authorSav, Aydin
dc.date.accessioned2024-09-18T20:29:51Z
dc.date.available2024-09-18T20:29:51Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe WHO categorises tumours based on their histological properties; however, this classification falls short of understanding their biological behaviours. Recently, there has been an increase in the number of studies on extracellular matrix components with the aim of understanding the biological behaviours of tumours. MMP-11 is a metalloproteinase from the MMP family that has a different expression pattern, mechanism of action, and substrate range compared with the other members of this family. Of the 55 benign meningioma cases examined, 29 were transitional, 16 were meningothelial, and 8 were fibroblastic in nature. In the meningotheliomatous cases, the MMP-11 expression score was high (75%), whereas it was low in the fibrous cases (87.5%). The Ki-67 levels in the cases with high MMP-11 expression scores were significantly higher than those of cases with low MMP-11 expression scores. Although there was no statistically significant correlation between recurrence and the MMP-11 expression score, 5 out of 7 cases with recurrence were found to have high MMP-11 expression scores. According to our study, MMP-11 is expressed in Grade I meningiomas. The level of MMP-11 expression appears to be high in the meningotheliomatous tumours and low in the fibrous subtypes. The tumours with a high level of MMP-11 expression also demonstrated high Ki-67 values.en_US
dc.identifier.endpage174en_US
dc.identifier.issn1302-1664
dc.identifier.issue1en_US
dc.identifier.startpage164en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11087
dc.identifier.volume31en_US
dc.identifier.wosWOS:000343369500023en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherJournal Neurological Sciencesen_US
dc.relation.ispartofJournal of Neurological Sciences-Turkishen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMeningiomaen_US
dc.subjectMMP11en_US
dc.subjectExtracellular Matrixen_US
dc.titleThe Expression of MMP-11 In Benign Meningiomasen_US
dc.typeArticleen_US

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