The relationship between anti-cyclic citrullinated peptide and bone mineral density and radiographic damage in patients with rheumatoid arthritis

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dc.contributor.authorGuler, H.
dc.contributor.authorTurhanoglu, A. D.
dc.contributor.authorOzer, B.
dc.contributor.authorOzer, C.
dc.contributor.authorBalci, A.
dc.date.accessioned2024-09-18T21:05:07Z
dc.date.available2024-09-18T21:05:07Z
dc.date.issued2008
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjectives: We aimed to investigate the relationship between anti-cyclic citrullinated peptide (anti-CCP) levels and bone mineral density (BMD), bone turnover, and radiographic damage in patients with rheumatoid arthritis (RA). Methods: Eighty patients (68 females, 12 males, mean age 46.50 +/- 14.59 years) with RA were included in the study. Anti-CCP antibodies were measured by enzyme-linked immunosorbent assay (ELISA). Bone turnover was studied by analysing serum levels of C-terminal telopeptide of type I collagen (sCTX, ng/mL), using an enzyme immunoassay. BMD was measured by dual-energy X-ray absorptiometry (DXA). Disease activity was assessed according to the Disease Activity Score that includes 28 joint counts (DAS28). Functional capacity was assessed by the Health Assessment Questionnaire (HAQ). Results: Anti-CCP-positive patients were defined as group 1 and anti-CCP-negative patients as group 2. The mean disease duration was 7.53 +/- 6.27 years in group 1 and 6.25 +/- 6.51 years in group 2. Anti-CCP had a limited negative correlation with lumbar BMD (r=-0.220, p=0.050) and a negative correlation with femoral BMD (r=-0.242, p=0.031). There was no statistically significant correlation between anti-CCP and sCTX values (r=0.117, p=0.301). Sharp scores were significantly higher in anti-CCP-positive than anti-CCP-negative patients (p=0.012), and anti-CCP levels were significantly correlated with Sharp scores (r=0.240, p=0.032). Conclusions: We found that RA patients with higher levels of anti-CCP antibody had lower lumbar and femoral BMD. Anti-CCP levels were also associated with radiographic damage. Therefore, we suggest that anti-CCP may be a determinant of bone loss in patients with RA.en_US
dc.identifier.doi10.1080/03009740801998812
dc.identifier.endpage342en_US
dc.identifier.issn0300-9742
dc.identifier.issn1502-7732
dc.identifier.issue5en_US
dc.identifier.pmid18609264en_US
dc.identifier.scopus2-s2.0-52949111438en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage337en_US
dc.identifier.urihttps://doi.org/10.1080/03009740801998812
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13377
dc.identifier.volume37en_US
dc.identifier.wosWOS:000259632000003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofScandinavian Journal of Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDisease-Activityen_US
dc.subjectPrognostic Valueen_US
dc.subjectSerum-Levelsen_US
dc.subjectAntibodiesen_US
dc.subjectAutoantibodiesen_US
dc.subjectProgressionen_US
dc.subjectOnseten_US
dc.subjectPredictionen_US
dc.subjectSeverityen_US
dc.subjectMarkersen_US
dc.titleThe relationship between anti-cyclic citrullinated peptide and bone mineral density and radiographic damage in patients with rheumatoid arthritisen_US
dc.typeArticleen_US

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