Dual effects of erdosteine on hemostasis via its different metabolites in young rats

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dc.authoridOktar, Suleyman/0000-0003-0151-5981
dc.contributor.authorArica, Vefik
dc.contributor.authorTutanc, Murat
dc.contributor.authorOzturk, Oktay Hasan
dc.contributor.authorArica, Secil
dc.contributor.authorBasarslan, Fatmagul
dc.contributor.authorErden, Ersin Sukru
dc.contributor.authorOktar, Suleyman
dc.date.accessioned2024-09-18T20:19:49Z
dc.date.available2024-09-18T20:19:49Z
dc.date.issued2011
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAim: In the study, we examined erdosteine's effects on platelet functions and coagulation. Materials and methods: A total 29 young albino Wistar rats were divided into four groups. Control rats (n = 6) were given saline; Group I rats (n = 7) were given 3 mg/kg erdosteine by oral gavage for 3 days; Group 2 rats (n = 7) were given 10 mg/kg erdosteine by oral gavage for 3 days; and Group 3 rats (n = 9) were given 30 mg/kg erdosteine for 3 days. Twenty-four hours after the final dose, blood samples were drawn from a portal vein. Prothrombin time (PT), activated partial thromboplastin time (aPTT) and international normalized ratio (INR) were measured, and platelet counts were examined in a peripheral blood smear by light microscopy. Results: PT and INR values of Group I increased compared to the controls but did not change in Group 3. Hemostatic parameters were not measured in Group 2 because the blood samples in Group 2's tubes clotted rapidly. Platelet counts of the peripheral blood from Group 2 were low but were normal in other groups. Conclusion: We have concluded erdosteine may disrupt hemostasis parameters by its different metabolites in patients. Erdosteine has dual effects on hemostasis via its different metabolites, which occur in different doses.en_US
dc.identifier.doi10.1177/0960327110396526
dc.identifier.endpage1648en_US
dc.identifier.issn0960-3271
dc.identifier.issue10en_US
dc.identifier.pmid21247989en_US
dc.identifier.scopus2-s2.0-80054854936en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1644en_US
dc.identifier.urihttps://doi.org/10.1177/0960327110396526
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9877
dc.identifier.volume30en_US
dc.identifier.wosWOS:000295812200025en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofHuman & Experimental Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecterdosteineen_US
dc.subjecthemostasisen_US
dc.subjectbleedingen_US
dc.subjectclottingen_US
dc.titleDual effects of erdosteine on hemostasis via its different metabolites in young ratsen_US
dc.typeArticleen_US

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