Effect of caffeic acid phenethyl ester on plasma lipid peroxidation, antioxidant status and nitric oxide levels in incisional wound model
[ N/A ]
Tarih
2007
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background and Design: Wound healing is a complex pathophysiologic process involving interplay of several cellular and biochemical processes. Several natural products have been shown to accelerate the healing process in studies. In this study we aimed to determine the efficacy of caffeic acid phenethyl ester (CAPE), which is an extract of honeybee propolis on wound healing in rats. Materials and Methods: Fourty male Wistar albino rats were divided into two groups as treatment (n=20) and control (n=20) group. A linear full thickness incision was performed on the back of each rat and sutured. After incision, during the study period CAPE was administered to the treatment group and saline was administered to the control group every day. Bloods of 5 animals from each group were collected on the experiment days of 1st, 3rd, 7th and 14th for biochemical analysis. Results: A significant increase in glutathione and nitric oxide levels and a significant decrease in malondialdehyde levels and superoxide dismutase activities in CAPE group were detected when compared to the control group. Conclusion: In the study it determined that CAPE showed an antioxidant effect on wound healing and suppressed lipid peroxidation. In conclusion, because of these properties, CAPE may be useful in wound healing.
Açıklama
Anahtar Kelimeler
Antioxidant status, Caffeic acid phenethyl ester, Lipid peroxidation, Wound healing
Kaynak
Turkderm Deri Hastaliklari ve Frengi Arsivi
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
41
Sayı
1
