A functional HOTAIR rs920778 polymorphism does not contributes to gastric cancer in a Turkish population: a case-control study

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dc.authoridSevgiler, Yusuf/0000-0002-4373-2389
dc.authoridSumbul, Ahmet Taner/0000-0002-5573-906X
dc.authoridGenc, Ahmet/0000-0002-9826-2396
dc.authoridBayram, Suleyman/0000-0002-7087-8615
dc.contributor.authorBayram, Suleyman
dc.contributor.authorUlger, Yakup
dc.contributor.authorSumbul, Ahmet Taner
dc.contributor.authorKaya, Berrin Yalinbas
dc.contributor.authorRencuzogullari, Ahmet
dc.contributor.authorGenc, Ahmet
dc.contributor.authorSevgiler, Yusuf
dc.date.accessioned2024-09-18T20:25:17Z
dc.date.available2024-09-18T20:25:17Z
dc.date.issued2015
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAn aberrant up-regulation of HOX transcript antisense intergenic RNA (HOTAIR), a long non-coding RNA (lncRNA), is associated with human cancers including gastric cancer (GC) and worse clinicopathological features. A naturally occurring functional single nucleotide polymorphism (SNP) rs920,778 (C -> T) in the intronic enhancer of HOTAIR gene has been demonstrated to affect HOTAIR expression and cancer susceptibility. To investigate the association of the HOTAIR rs920778 polymorphism on the risk of GC susceptibility in Turkish population, a hospital-based case-control study was carried out consisting of 104 GC and 209 healthy control subjects matched on age and gender. The genotype frequency of HOTAIR rs920778 polymorphism was determined by using TaqMan Real-Time Polymerase Chain Reaction. No statistically significant differences were found in the allele or genotype distributions of the HOTAIR rs920778 polymorphism among GC and healthy control subjects (P > 0.05). Our results demonstrate that the HOTAIR rs920778 polymorphism has not been in any major role in genetic susceptibility to gastric carcinogenesis, at least in the population studied here. Independent studies are needed to validate our findings in a larger series, as well as in patients of different ethnic origins.en_US
dc.description.sponsorshipAdiyaman University [SYOBAP/2013-0001]en_US
dc.description.sponsorshipThe author thanks all the subjects who participated in this study. The authors also would like to thank all Adiyaman University Scientific Research Unit staffs (Sel, A.; Ilgin, K.; Elbir, F.; Isik, Y.; Abaci, U.). We also would like to thank Dr. Muhsin Aydin for very helpful English corrections. This work was supported by Adiyaman University Research Fund SYOBAP/2013-0001.en_US
dc.identifier.doi10.1007/s10689-015-9813-0
dc.identifier.endpage567en_US
dc.identifier.issn1389-9600
dc.identifier.issn1573-7292
dc.identifier.issue4en_US
dc.identifier.pmid25980897en_US
dc.identifier.scopus2-s2.0-84946472132en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage561en_US
dc.identifier.urihttps://doi.org/10.1007/s10689-015-9813-0
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10217
dc.identifier.volume14en_US
dc.identifier.wosWOS:000364223300009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofFamilial Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGastric canceren_US
dc.subjectHOTAIRen_US
dc.subjectlncRNAen_US
dc.subjectHOTAIR rs920778 polymorphismen_US
dc.subjectGenetic susceptibilityen_US
dc.titleA functional HOTAIR rs920778 polymorphism does not contributes to gastric cancer in a Turkish population: a case-control studyen_US
dc.typeArticleen_US

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