The endothelial nitric oxide synthase (eNOS) polymorphism in otitis media with effusion (OME)

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dc.authoridDokuyucu, Recep/0000-0001-7881-8871
dc.authoridIzmirli, Muzeyyen/0000-0002-8545-863X
dc.authoridDokuyucu, Recep/0000-0001-6837-3477
dc.contributor.authorAtes, M.
dc.contributor.authorCevik, C.
dc.contributor.authorDokuyucu, Recep
dc.contributor.authorBerber, O.
dc.contributor.authorColak, S.
dc.contributor.authorIzmirli, M.
dc.date.accessioned2024-09-18T20:53:00Z
dc.date.available2024-09-18T20:53:00Z
dc.date.issued2017
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjectives: Otitis media with effusion (OME) is the most common disease after viral infections of upper respiratory tract (URTI) in children. Studies indicate the important role of nitric oxide (NO) in the etiology of hearing loss. However, there is no study that focuses on the role of nitric oxide synthase (eNOS) polymorphisms in the cases with OME. The aim of the present study is to evaluate the eNOS polymorphisms in the pediatric patients with OME. Materials and methods: Eighty-nine patients who are diagnosed with otitis media with effusion and 85 healthy subjects who are compatible in terms of age and gender were included in the study. All patients in the study were subjected to complete ear, nose, throat (ENT) and audiological examinations. DNA analysis was performed with polymerase chain reaction (PCR) technique from the blood samples. The PCR product was cut by restriction fragment length polymorphism (RFLP) with BanII enzyme and checked by agarose gel electrophoresis. Results: As a result of genetic analysis, there is no significant difference between patients and the controls in terms of eNOS Glu298Asp polymorphism (G/G, G/T, T/T). When these groups were compared in terms of allele distributions, a significant relationship was found between the patients and the controls (P = 0.037). Conclusion: To the best of our knowledge, G allele was identified as predisposing to the development of OME and this is the first report indicates the correlation between the eNOS G894T polymorphism and OME in Turkey. (C) 2016 Elsevier Masson SAS. All rights reserved.en_US
dc.description.sponsorshipMustafa Kemal University Scientific Research Project Coordination [10862]en_US
dc.description.sponsorshipThis study with 10862 ID number was supported by Mustafa Kemal University Scientific Research Project Coordination.en_US
dc.identifier.doi10.1016/j.anorl.2015.10.004
dc.identifier.endpage5en_US
dc.identifier.issn1879-7296
dc.identifier.issn1879-730X
dc.identifier.issue1en_US
dc.identifier.pmid27131733en_US
dc.identifier.scopus2-s2.0-84964582918en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage3en_US
dc.identifier.urihttps://doi.org/10.1016/j.anorl.2015.10.004
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11529
dc.identifier.volume134en_US
dc.identifier.wosWOS:000393323700002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Masson, Corporation Officeen_US
dc.relation.ispartofEuropean Annals of Otorhinolaryngology-Head and Neck Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOtitis media with effusionen_US
dc.subjecteNOS polymorphismen_US
dc.subjectSerous otitisen_US
dc.subjectTurkeyen_US
dc.titleThe endothelial nitric oxide synthase (eNOS) polymorphism in otitis media with effusion (OME)en_US
dc.typeArticleen_US

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