WHAT IS THE CLINICAL SIGNIFICANCE OF MIXED APNEA IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA: A RETROSPECTIVE STUDY

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dc.authoridDEMIRKOSE, MESUT/0000-0003-3862-4567
dc.contributor.authorGenc, Sebahat
dc.contributor.authorTuncel, Ertan
dc.contributor.authorSavas, Nazan
dc.contributor.authorDemirkose, Mesut
dc.contributor.authorDikmen, Nursel
dc.date.accessioned2024-09-18T20:57:05Z
dc.date.available2024-09-18T20:57:05Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAim: Mixed apnea is defined as absent inspiratory effort in the initial portion of apnea, followed by resumption of inspiratory effort in the second portion. However, the pathophysiological and clinical significance of mixed apnea has not been well defined. This study investigated the likely clinical importance of mixed apnea. Materials and methods: Patients diagnosed with severe obstructive sleep apnea (OSA) in polysomnographic studies were enrolled. Those with a mixed-apnea index value of 5/h or higher were grouped as mixed-OSA (Group 1), and those with a mixed-apnea index value below 1/h were grouped as pure-OSA (Group 2). The patients' demographics, symptoms, clinical and polysomnographic findings, and laboratory examination results were reviewed retrospectively. Results: Groups 1 and 2 contained 24 and 42 patients, respectively. The mean age was significantly lower in Group I than those in Group 2 (47.4 +/- 10.4 vs 52.2 +/- 8.3, respectively, p<0.05). The patients in Group I displayed significantly higher apnea / hypopnea index (AHI) values (p <0.001). Sleep duration, arousal index, and duration of apneas were significantly higher in Group 1 (p=0,006, p=0.013, p=0.008, respectively). While minimum oxygen saturation and mean oxygen saturation levels were significantly lower (p<0.001), mean oxygen desaturation percentages were significantly higher in Group 1 than those in Group 2 (p=0,001). Conclusions: These findings suggest that mixed apnea is not just a subtype of obstructive apnea, and OSA with mixed apnea can be referred as a different fenotype of OSAS. Although there are studies about the alterations in neurochemical control of respiration, pathophysiology is not yet clear. So new studies are needed to investigate the underlying pathophysiology and and clinical outcome.en_US
dc.identifier.endpage528en_US
dc.identifier.issn0393-6384
dc.identifier.issn2283-9720
dc.identifier.issue2en_US
dc.identifier.startpage523en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12280
dc.identifier.volume30en_US
dc.identifier.wosWOS:000335937900039en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherCarbone Editoreen_US
dc.relation.ispartofActa Medica Mediterraneaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSleep apneaen_US
dc.subjectmixed apneaen_US
dc.subjectcentral apneaen_US
dc.subjectintermittent hypoxiaen_US
dc.titleWHAT IS THE CLINICAL SIGNIFICANCE OF MIXED APNEA IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA: A RETROSPECTIVE STUDYen_US
dc.typeArticleen_US

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