Peripapillary Retinal Nerve Fiber Layer and Ganglion Cell-Inner Plexiform Layers Thickness in Ankylosing Spondylitis

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dc.contributor.authorTuzcu, Esra Ayhan
dc.contributor.authorUstun, Nilgul
dc.contributor.authorIlhan, Nilufer
dc.contributor.authorYagiz, Erman
dc.contributor.authorDaglioglu, Mutlu Cihan
dc.contributor.authorCoskun, Mesut
dc.contributor.authorIlhan, Ozgur
dc.date.accessioned2024-09-18T19:54:24Z
dc.date.available2024-09-18T19:54:24Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: To assess the thickness of the retinal nerve fibril layer (RNFL) in cases with ankylosing spondylitis (AS). Materials and methods: The study included 40 AS patients who had no history of acute and/or previous uveitis and 50 healthy controls. After detailed ocular examination, the thickness of the peripapillary RNFL, the macula, and the ganglion cell-inner plexiform layers (GCIPL) were measured by spectral domain optic coherence tomography (SD-OCT). The correlation between the duration of the disease and the thickness of the RNFL, the macula, and the GCIPL were analyzed in the patients who had AS. These patients were then placed into 2 groups according to their BASDAI (Bath Ankylosing Spondylitis Disease Activity Index) score: patients with BASDAI score <4 and those with BASDAI score >= 4. The correlations between the BASDAI score and the mean GCIPL and temporal RNFL thickness were evaluated. Results: No significant difference was detected in the RNFL thickness of the AS patients and that of the controls (p = 0.407). Nor was any significant difference detected in the GCIPL thickness of the AS and the control groups (p = 0.091). In addition, no significant difference was found in the macular thickness when the AS group was compared to the control group (p = 0.139). However, a negative correlation was detected between the duration of the disease and the thickness of the temporal quadrant RNFLs (r = -0.334; p = 0.035). The temporal quadrant RNFL thickness and the mean thickness of the GCPIL were significantly thinner in the AS patients with BASDAI score >= 4 (p = 0.034 and p = 0.025, respectively). Also, the BASDAI score were negatively correlated to the temporal quadrant RNFL and GCIPL thickness (r = -0.332; p = 0.036 and r = -0.348; p = 0.028, respectively). Conclusion: RNFL thickness and GCIPL thickness of ankylosing spondylitis may be affected by the severity and duration of the disease.en_US
dc.identifier.doi10.3109/09273948.2014.938760
dc.identifier.endpage433en_US
dc.identifier.issn0927-3948
dc.identifier.issn1744-5078
dc.identifier.issue6en_US
dc.identifier.pmid25084313en_US
dc.identifier.scopus2-s2.0-84922264886en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage429en_US
dc.identifier.urihttps://doi.org/10.3109/09273948.2014.938760
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7714
dc.identifier.volume22en_US
dc.identifier.wosWOS:000345209300002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofOcular Immunology and Inflammationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnkylosing spondylitisen_US
dc.subjectdisease activityen_US
dc.subjectganglion cell-inner plexiform layeren_US
dc.subjectretinal nerve fiber layeren_US
dc.subjectthicknessen_US
dc.titlePeripapillary Retinal Nerve Fiber Layer and Ganglion Cell-Inner Plexiform Layers Thickness in Ankylosing Spondylitisen_US
dc.typeArticleen_US

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