Efflux pump genes and antimicrobial resistance of Pseudomonas aeruginosa strains isolated from lower respiratory tract infections acquired in an intensive care unit

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dc.contributor.authorOzer, Burcin
dc.contributor.authorDuran, Nizami
dc.contributor.authorOnlen, Yusuf
dc.contributor.authorSavas, Lutfu
dc.date.accessioned2024-09-18T20:28:08Z
dc.date.available2024-09-18T20:28:08Z
dc.date.issued2012
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe aim of this study was to determine the antimicrobial resistance rates and the resistance genes associated with efflux pumps of Pseudomonas aeruginosa strains isolated from the patients who acquired lower respiratory tract infection (LRTI) in intensive care unit (ICU). Fifty P. aeruginosa strains isolated from the lower respiratory tract specimens of the patients who acquired LRTIs in ICU were included in this study. P. aeruginosa strains were isolated from tracheal aspirate (27), bronchoalveolar lavage (14) and sputum (9). The susceptibilities of the isolates were investigated by the disk diffusion method. Multiplex PCR assay was carried out for the detection of 13 antibiotic-resistance genes. Antimicrobial resistance rates of the isolates were found high and the highest resistance rate of the isolates studied was determined against to mezlocillin (50%) followed by norfloxacin (48%), ciprofloxacin (46%), meropenem (40%). Fourty-three isolates (86%) were determined to carry one and more resistance genes. NfxB gene was most often determined in the genes that were investigated. The significant relation between the resistance to cefepime, piperacilline/tazobactam and the mexC gene, that between the resistance to mezlocillin, piperacilline/tazobactam, ceftazidime, cefepime and ampC genes, and that between the resistance to ciprofloxacin, norfloxacin and oprJ, oprN and nfxB genes was identified. Resistance caused by genes for carbapenemases, aminoglycoside-modifying enzymes and other mechanisms were not identified in this study. Understanding the prevalence and mechanism of antimicrobial resistance in P. aeruginosa may help to select empirical therapy for nosocomial LRTIs due to P. aeruginosa in our ICU. The Journal of Antibiotics (2012) 65, 9-13; doi: 10.1038/ja.2011.102; published online 16 November 2011en_US
dc.description.sponsorshipMustafa Kemal University [BAP 08T 1701]en_US
dc.description.sponsorshipThis work was granted by Mustafa Kemal University Scientific Research Projects (BAP 08T 1701).en_US
dc.identifier.doi10.1038/ja.2011.102
dc.identifier.endpage13en_US
dc.identifier.issn0021-8820
dc.identifier.issn1881-1469
dc.identifier.issue1en_US
dc.identifier.pmid22086166en_US
dc.identifier.scopus2-s2.0-84856497696en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage9en_US
dc.identifier.urihttps://doi.org/10.1038/ja.2011.102
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10755
dc.identifier.volume65en_US
dc.identifier.wosWOS:000300004200002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringernatureen_US
dc.relation.ispartofJournal of Antibioticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectintensive care uniten_US
dc.subjectlower respiratory tract infectionen_US
dc.subjectP. aeruginosaen_US
dc.subjectresistance genesen_US
dc.titleEfflux pump genes and antimicrobial resistance of Pseudomonas aeruginosa strains isolated from lower respiratory tract infections acquired in an intensive care uniten_US
dc.typeArticleen_US

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