A novel tumor suppressor gene in basal cell carcinoma: inhibition of growth factor-2

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dc.authoridtemel, metin/0000-0002-1829-9894
dc.authoridDokuyucu, Recep/0000-0001-6837-3477
dc.authoridTurkmen, Arif/0000-0001-8774-830X
dc.authoridDokuyucu, Recep/0000-0001-7881-8871
dc.contributor.authorTemel, Metin
dc.contributor.authorTurkmen, Arif
dc.contributor.authorDokuyucu, Recep
dc.contributor.authorCevik, Cengiz
dc.contributor.authorOztuzcu, Serdar
dc.contributor.authorCengiz, Beyhan
dc.contributor.authorMutaf, Mehmet
dc.date.accessioned2024-09-18T20:02:54Z
dc.date.available2024-09-18T20:02:54Z
dc.date.issued2015
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIn loss of heterozygosity (LOH) studies at the chromosome 4q22-35 region, it was shown that the amount of deletion was high in basal cell carcinoma (BCC). It has been proposed that genes located in this chromosomal region could be tumor suppressor genes in BCC. It has been thought that deletions in the ING2 gene located in the same region can play a role in the pathophysiology of BCC and that deletions occurring in this region may influence the level of ING2 expression in BCC. Tumoral and non-tumoral tissues from 75 patients with BCC (45 men and 30 women) were included to the study. Lesions were excised by a surgical margin of 0.5 cm. After excision, RNA was isolated from tumoral and non-tumoral tissue samples. ING2 messenger RNA (mRNA) expression level was determined in tumoral and non-tumoral tissues by the real-time polymerase chain reaction (RT-PCR). It was detected that ING2 mRNA expression level decreased in tumoral tissues when compared to non-tumoral tissues from BCC patients (p = 0.0001). It was found that expression levels of this gene were comparable among patients with primary, recurrent, or multiple BCC. It is thought that ING2 gene expression level could contribute to the development of BCC but not be associated with the stage and the prognosis of the tumor.en_US
dc.description.sponsorshipGaziantep University Scientific Research Project Coordination [TF.11.11]en_US
dc.description.sponsorshipThis study with TF.11.11 ID number was supported by Gaziantep University Scientific Research Project Coordination.en_US
dc.identifier.doi10.1007/s13277-015-3108-9
dc.identifier.endpage4616en_US
dc.identifier.issn1010-4283
dc.identifier.issn1423-0380
dc.identifier.issue6en_US
dc.identifier.pmid25613071en_US
dc.identifier.scopus2-s2.0-84938994370en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage4611en_US
dc.identifier.urihttps://doi.org/10.1007/s13277-015-3108-9
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8081
dc.identifier.volume36en_US
dc.identifier.wosWOS:000359383700070en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofTumor Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBasal cell carcinomasen_US
dc.subjectTumor suppressor genesen_US
dc.subjectING gene familyen_US
dc.subjectSkin canceren_US
dc.subjectUV radiationen_US
dc.titleA novel tumor suppressor gene in basal cell carcinoma: inhibition of growth factor-2en_US
dc.typeArticleen_US

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