SIRT1 Gene Polymorphisms Affect the Protein Expression in Cardiovascular Diseases

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dc.authoriduysal, omer/0000-0002-8833-697X
dc.authoridElibol, Birsen/0000-0002-9462-0862
dc.authoridIzmirli, Muzeyyen/0000-0002-8545-863X
dc.contributor.authorKilic, Ulkan
dc.contributor.authorGok, Ozlem
dc.contributor.authorBacaksiz, Ahmet
dc.contributor.authorIzmirli, Muzeyyen
dc.contributor.authorElibol-Can, Birsen
dc.contributor.authorUysal, Omer
dc.date.accessioned2024-09-18T21:06:34Z
dc.date.available2024-09-18T21:06:34Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractCardiovascular disease (CVD), the leading cause of death worldwide, is related to gene-environment interactions due to epigenetic factors. SIRT1 protein and its downstream pathways are critical for both normal homeostasis and protection from CVD-induced defects. The aim of this study was to investigate the association between SIRT1 single nucleotide polymorphisms (SNPs) (rs7895833 A>G in the promoter region, rs7069102 C>G in intron 4 and rs2273773 C>T in exon 5 silent mutation) and SIRT1 and eNOS (endothelial nitric oxide synthase) protein expression as well as total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) in CVD patients as compared to controls. The frequencies of mutant genotypes and alleles for rs7069102 and rs2273773 were significantly higher in patients with CVD compared to control group. The risk for CVD was increased by 2.4 times for rs7069102 and 1.9 times for rs2273773 in carriers of mutant allele compared with carriers of wild-type allele pointing the protective role of C allele for both SNPs against CVD. For rs7895833, there was no significant difference in genotype and allele distributions between groups. SIRT1 protein, TAS, TOS and OSI levels significantly increased in patients as compared to control group. In contrast, level of eNOS protein was considerably low in the CVD patients. An increase in the SIRT1 expression in the CVD patients carrying mutant genotype for rs7069102 and heterozygote genotype for all three SNPs was observed. This is the first study reporting an association between SIRT1 gene polymorphisms and the levels of SIRT1 and eNOS expressions as well as TAS, TOS and OSI.en_US
dc.description.sponsorshipUniversity Research Council, Bezmialem Vakif University [BAP:6.2013/21]en_US
dc.description.sponsorshipThis study was supported by grants from the University Research Council, Bezmialem Vakif University (BAP:6.2013/21). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en_US
dc.identifier.doi10.1371/journal.pone.0090428
dc.identifier.issn1932-6203
dc.identifier.issue2en_US
dc.identifier.pmid24587358en_US
dc.identifier.scopus2-s2.0-84896498683en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0090428
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13693
dc.identifier.volume9en_US
dc.identifier.wosWOS:000332396200193en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPublic Library Scienceen_US
dc.relation.ispartofPlos Oneen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNitric-Oxide Synthaseen_US
dc.subjectCoronary-Artery-Diseaseen_US
dc.subjectOxidative Stressen_US
dc.subjectMyocardial-Infarctionen_US
dc.subjectHeart-Diseaseen_US
dc.subjectMiceen_US
dc.subjectActivationen_US
dc.subjectPromotesen_US
dc.subjectDnaen_US
dc.subjectAtherosclerosisen_US
dc.titleSIRT1 Gene Polymorphisms Affect the Protein Expression in Cardiovascular Diseasesen_US
dc.typeArticleen_US

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