Assessment of Ischemia Modified Albumin as a Marker of Oxidative Stress in Chronic Kidney Disease
[ N/A ]
Tarih
2021
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wolters Kluwer Medknow Publications
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Increased oxidative stress (OS) in chronic kidney disease (CKD), and particularly in those undergoing hemodialysis (HD), is widely recognized. We aimed to evaluate ischemia modified albumin (IMA) as a marker of OS in CKD patients who are not yet on HD compared to chronic HD patients. A cross-sectional study was conducted in Hitit University, Corum, Turkey in 2015. In this study, 39 chronic HD and 36 CKD patients in stage 3-4 were included, as well as 34 healthy individuals as a control group. IMA levels in HD patients (before and after HD session), stage 3-4 CKD patients and control group were evaluated using the ELISA method. Pre-HD and post-HD albumin levels were measured and albumin-adjusted IMA (aIMA) levels were calculated. IMA and aIMA levels were higher in chronic HD and CKD patients who are not yet on HD, compared to healthy individuals (IMA, 179.76 +/- 60.46, 209.67 +/-& nbsp; 69.84, 67.41 +/- 32.22, P < 0.001, respectively, aIMA, 186.22 +/-& nbsp; 64.84, 212.96 +/-& nbsp; 72.84, 68.80 +/- ; 34.42, P < 0.001, respectively). Likewise, IMA and aIMA levels in post-HD patients were higher than pre-HD levels (IMA, 294.62 +/- 66.64, 179.76 +/-& nbsp; 60.46, P < 0.001, respectively, aIMA, 298.31 +/-& nbsp; 70.93, 186.22 & PLUSMN; 64.83, P < 0.001). Linear regression analysis identified glomerular filtration rate as the most effective factor on IMA (P < 0.001). CKD is associated with increased OS and the HD procedure itself also contributes to the increase in OS. IMA may serve as a feasible biomarker for determination of OS.& nbsp;
Açıklama
Anahtar Kelimeler
Myocardial-Ischemia, Hemodialysis, Biomarkers, Binding, Protein, Assay
Kaynak
Saudi Journal of Kidney Diseases and Transplantation
WoS Q Değeri
N/A
Scopus Q Değeri
Q3
Cilt
32
Sayı
4
