Erdosteine against acetaminophen induced Renal toxicity

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dc.authoridBayrak, Reyhan/0000-0001-7450-9828
dc.contributor.authorIsik, Bunyamin
dc.contributor.authorBayrak, Reyhan
dc.contributor.authorAkcay, Ali
dc.contributor.authorSogut, Sadik
dc.date.accessioned2024-09-18T19:48:02Z
dc.date.available2024-09-18T19:48:02Z
dc.date.issued2006
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAcetaminophen (APAP) induced toxicities have been a major problem in clinical practice. The aim of the present study was to demonstrate a possible protective role of erdosteine, a mucolytic agent having antioxidant properties via its active metabolites, on APAP induced renal damage in rats. Female Wistar Albino rats were divided into groups including control, erdosteine (150 mg/kg, oral), APAP (1 g/kg, oral) APAP+erdosteine (150 mg/kg, oral) and APAP+erdosteine (300 mg/kg, oral). APAP treatment caused lipid peroxidation as well as high NO level in renal tissue. Also, APAP treated rats had decreased activities of CAT and GSH-Px, but not SOD. In addition, tubular epithelial degeneration, vacuolization and cell desquamation were clearly observed in the APAP treated rats. The cellular debris in the proximal tubules and cortical interstitial congestions were prominent in the kidneys of APAP treated rats. BUN and creatinine levels were increased after APAP administration. All these pathological changes were reversed after erdosteine treatments. Erdosteine treated APAP groups showed milder tubular degeneration, epithelial vacuolization in the proximal tubules, lesser cellular desquamation and better morphology when compared with APAP groups. In conclusion, erdosteine may be a choice of preventive treatment against APAP induced nephrotoxicity.en_US
dc.identifier.doi10.1007/s11010-005-9110-6
dc.identifier.endpage191en_US
dc.identifier.issn0300-8177
dc.identifier.issn1573-4919
dc.identifier.issue1-2en_US
dc.identifier.pmid16532256en_US
dc.identifier.scopus2-s2.0-33745964551en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage185en_US
dc.identifier.urihttps://doi.org/10.1007/s11010-005-9110-6
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7312
dc.identifier.volume287en_US
dc.identifier.wosWOS:000239022600020en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofMolecular and Cellular Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectacetaminophenen_US
dc.subjecterdosteineen_US
dc.subjectrenal toxicityen_US
dc.subjectoxidanten_US
dc.subjectantioxidanten_US
dc.titleErdosteine against acetaminophen induced Renal toxicityen_US
dc.typeArticleen_US

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