The effect of tyrosol on diclofenac sodium-induced acute nephrotoxicity in rats

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dc.authoridGOKCEK, ISHAK/0000-0002-0590-6405
dc.authoridGUVENC, MEHMET/0000-0002-9716-0697
dc.authoridCOMEZ, MEHMET/0000-0003-0821-5148
dc.authoridEtyemez, Muhammed/0000-0003-0497-1878
dc.authoridKUZU, Muslum/0000-0002-1375-7673
dc.authoridTURK, ERDINC/0000-0003-1735-1774
dc.contributor.authorComez, Mehmet
dc.contributor.authorCellat, Mustafa
dc.contributor.authorKuzu, Muesluem
dc.contributor.authorUyar, Ahmet
dc.contributor.authorTurk, Erdinc
dc.contributor.authorKaya, Yusuf Selim
dc.contributor.authorEtyemez, Muhammed
dc.date.accessioned2024-09-18T19:54:31Z
dc.date.available2024-09-18T19:54:31Z
dc.date.issued2024
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAlthough diclofenac (DCF) is a nonsteroidal anti-inflammatory drug that is considered safe, its chronic use and overdose may show some toxic effects. The protective effect of tyrosol (Tyr) pretreatment against DCF-induced renal damage was investigated in this study. The 32 rats used in the study were randomly divided into four groups of eight rats each. According to the data obtained, it was determined that creatinine, urea, and blood urea nitrogen (BUN) levels increased in serum samples of the DCF group. Besides, the levels of reduced glutathione (GSH) and glutathione peroxidase (GPx) activity decreased and the malondialdehyde (MDA) level increased in the kidney tissue. However, no change was observed in catalase (CAT) activity. Cyclooxygenase-2 (COX-2), nuclear factor kappa B (NF-kappa B), and tumor necrosis factor-alpha (Tnf-alpha) levels increased and nuclear factor erythroid 2-related factor 2 (Nrf-2) levels decreased. No change was detected in the level of interleukin 1 beta (IL-1 beta). When the DCF+Tyr group and the DCF group were compared, it was assessed that Tyr had a curative effect on all biochemical parameters. Also, kidney damages, such as degeneration and necrosis of tubular epithelium and congestion of veins, were obviated by treatment with tyrosol in histopathological examinations. It was determined that Tyr pretreatment provided a protective effect against nephrotoxicity induced by DCF with its anti-inflammatory and antioxidant properties.en_US
dc.description.sponsorshipThis study was funded by the Scientific Research Project Coordination of the Hatay Mustafa Kemal University, Turkey (No: 20.M.013/2020). [20]; Scientific Research Project Coordination of the Hatay Mustafa Kemal University, Turkeyen_US
dc.description.sponsorshipThis study was funded by the Scientific Research Project Coordination of the Hatay Mustafa Kemal University, Turkey (No: 20.M.013/2020).en_US
dc.identifier.doi10.1002/jbt.23582
dc.identifier.issn1095-6670
dc.identifier.issn1099-0461
dc.identifier.issue1en_US
dc.identifier.pmid37975510en_US
dc.identifier.scopus2-s2.0-85177050046en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/jbt.23582
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7782
dc.identifier.volume38en_US
dc.identifier.wosWOS:001106340200001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Biochemical and Molecular Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectanti-inflammatoryen_US
dc.subjectantioxidanten_US
dc.subjectdiclofenacen_US
dc.subjectnephrotoxicityen_US
dc.subjecttyrosolen_US
dc.titleThe effect of tyrosol on diclofenac sodium-induced acute nephrotoxicity in ratsen_US
dc.typeArticleen_US

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