Effects of Dexamethasone on Bupivacaine-Induced Peripheral Nerve Injection Injury in the Rat Sciatic Model

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dc.authoridGUVENC, MEHMET/0000-0002-9716-0697
dc.authoridCOMEZ, MEHMET/0000-0003-0821-5148
dc.contributor.authorComez, Mehmet Selim
dc.contributor.authorBorazan, Yakup
dc.contributor.authorOzgur, Tumay
dc.contributor.authorIsler, Cafer Tayer
dc.contributor.authorCellat, Mustafa
dc.contributor.authorGuvenc, Mehmet
dc.contributor.authorAltug, Muhammed Enes
dc.date.accessioned2024-09-18T20:33:10Z
dc.date.available2024-09-18T20:33:10Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIntroduction The aim of this study was to investigate the effect of perineural dexamethasone against intraneural bupivacaine. Material and Methods Rats were divided into 9 groups with 6 animals in each group; Group 1 (Intraneural saline 600 mu L-2ndday), Group 2 (Intraneural saline 600 mu L-7th day), Group 3 (Intraneural saline 600 mu L + perineural dexamethasone 0.5 mg/kg-2nd day), Group 4 (Intraneural saline 600 mu L + perineural dexamethasone 0.5 mg/kg-7th day), Group 5 (Intraneural bupivacaine 10 mg/kg-2nd day), Group 6 (Intranueral bupivacaine 10 mg/kg-7th day), Group 7 (Intraneural bupivacaine 10 mg/kg + perineurald exam ethasone 0.5 mg/kg-2nd day), Group 8 (Intraneural bupivacaine 10 mg/kg + perineural dexamethasone 0.5 mg/kg-7th day), Group 9 (Control group). At the end of the application period, histopathological and immunohistochemical examinations were analyzed. Results and Conclusion It was observed that caspase 3 levels significantly increased in the 5th and 6th groups compared to the 1st and 2nd groups (p < 0.01). However, in the 7th and 8th groups, these levels were similar with 1st and 2nd groups. While a significant decrease in S 100 levels was detected in group 6 (p < 0.05), a significant increase occurred in Group 8 and reached the same levels as Group 2. According to histopathological evaluation, edema, vacuolization and myelin degeneration were significantly increased in groups 5 and 6 (p < 0.05). However, in the 8th group, the mentioned data showed a significant decrease and reached the same levels as group 2. As a result, perineural dexamethasone was found to have protective effects against intraneural bupivacaine induced sciatic nerve damage.en_US
dc.description.sponsorshipScientific Research Project Coordination of the Hatay Mustafa Kemal University, Turkey [18.M.100/2018]en_US
dc.description.sponsorshipThis study funded by the Scientific Research Project Coordination of the Hatay Mustafa Kemal University, Turkey (No. 18.M.100/2018).en_US
dc.identifier.doi10.1080/08941939.2020.1805053
dc.identifier.endpage1347en_US
dc.identifier.issn0894-1939
dc.identifier.issn1521-0553
dc.identifier.issue12en_US
dc.identifier.pmid32781870en_US
dc.identifier.scopus2-s2.0-85089448320en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1339en_US
dc.identifier.urihttps://doi.org/10.1080/08941939.2020.1805053
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11333
dc.identifier.volume34en_US
dc.identifier.wosWOS:000558509200001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal of Investigative Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNerve injuryen_US
dc.subjectdexamethasoneen_US
dc.subjectbupivacaineen_US
dc.titleEffects of Dexamethasone on Bupivacaine-Induced Peripheral Nerve Injection Injury in the Rat Sciatic Modelen_US
dc.typeArticleen_US

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