T-786C Polymorphism in Promoter of eNOS Gene as Genetic Risk Factor in Patients With Erectile Dysfunction in Turkish Population

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dc.authoridSINICI LAY, INCILAY/0000-0002-1466-5746
dc.authoridGuven, Esref Oguz/0000-0003-4919-9383
dc.contributor.authorSinici, Incilay
dc.contributor.authorGuven, E. Oguz
dc.contributor.authorSerefoglu, Egecan
dc.contributor.authorHayran, Mutlu
dc.date.accessioned2024-09-18T21:03:11Z
dc.date.available2024-09-18T21:03:11Z
dc.date.issued2010
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractOBJECTIVES To investigate the effect of 2 endothelial nitric oxide synthase gene polymorphisms, namely, variable number of 27-bp tandem repeats in intron 4 and T-786C in the promoter region, on the susceptibility to erectile dysfunction (ED) in Turkish population. METHODS A total of 72 patients with ED (mean age 54.3 +/- 9.2 years) diagnosed by Doppler ultrasonography and 71 healthy controls (mean age 55.4 +/- 8.2 years) were analyzed. Genotypes were determined through polymerase chain reaction with or without restriction endonuclease digestions. RESULTS Genotype distribution for CC genotype of T-786C polymorphism in promoter was significantly different between patients with ED and controls, the genotype frequency being 31.9% and 12.7%, respectively (P = .019). The univariate odds ratio (OR) associated with CC alleles revealed 3 times increased risk for ED (OR = 3.2; 95% confidence interval [CI], 1.4-7.6; P = .006). The risk also holds when excluding patients with hypertension and diabetes mellitus (P = .012, OR = 3.1; 95% CI, 1.2-7.7) as well as obesity (P = .05, OR = 4; 95% CI, 1.05-15.3). Patients with CC genotype of promoter present earlier symptoms of ED (51.7%) compared with controls (10.7%) (P < .001). No significant correlation was observed with variable number of tandem repeats in intron 4 and with the type of vascular insufficiency. CONCLUSIONS The CC genotype of T-786C polymorphism in the promoter of eNOS gene is associated with increased risk of ED in Turkish population. Earlier onset of ED with CC genotype suggests that CC allele is an independent risk factor for endothelial dysfunction in the absence of other risk factors (hypertension, diabetes mellitus, obesity). An impaired NO production because of CC alleles may account for pathophysiology of ED. UROLOGY 75: 955-960, 2010. (C) 2010 Elsevier Inc.en_US
dc.identifier.doi10.1016/j.urology.2009.06.063
dc.identifier.endpage960en_US
dc.identifier.issn0090-4295
dc.identifier.issn1527-9995
dc.identifier.issue4en_US
dc.identifier.pmid19800665en_US
dc.identifier.scopus2-s2.0-77950301044en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage955en_US
dc.identifier.urihttps://doi.org/10.1016/j.urology.2009.06.063
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13293
dc.identifier.volume75en_US
dc.identifier.wosWOS:000276258300036en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofUrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNitric-Oxide Synthaseen_US
dc.subjectGlu298aspen_US
dc.subjectAssociationen_US
dc.subjectPrevalenceen_US
dc.subjectSildenafilen_US
dc.subjectExpressionen_US
dc.subjectMediatoren_US
dc.subjectMutationen_US
dc.subjectDiseaseen_US
dc.subjectEnzymeen_US
dc.titleT-786C Polymorphism in Promoter of eNOS Gene as Genetic Risk Factor in Patients With Erectile Dysfunction in Turkish Populationen_US
dc.typeArticleen_US

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