Zingerone protects liver and kidney tissues by preventing oxidative stress, inflammation, and apoptosis in methotrexate-treated rats

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dc.authoridKUZU, Muslum/0000-0002-1375-7673
dc.authoridKirbas, Akin/0000-0001-9159-3240
dc.authoridAGGUL, AHMET GOKHAN/0000-0003-0377-0388
dc.authoridGUVENC, MEHMET/0000-0002-9716-0697
dc.authoridTURK, ERDINC/0000-0003-1735-1774
dc.authoridUyar, Ahmet/0000-0003-4345-6756
dc.contributor.authorTurk, Erdinc
dc.contributor.authorGuvenc, Mehmet
dc.contributor.authorCellat, Mustafa
dc.contributor.authorUyar, Ahmet
dc.contributor.authorKuzu, Muslum
dc.contributor.authorAggul, Ahmet Gokhan
dc.contributor.authorKirbas, Akin
dc.date.accessioned2024-09-18T20:32:50Z
dc.date.available2024-09-18T20:32:50Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe clinical use of drugs used in the treatment of diseases is limited due to the toxic side effects, and many studies have been conducted to benefit from herbal adjuvant therapies recently to eliminate these effects. In this study, the protective effect of zingerone against liver and kidney damage generated in rats through methotrexate (MTX). Histopathological investigations were performed to determine tissue damage caused by MTX and the healing effect of zingone and liver function markers such as serum alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), and renal function markers such as urea, creatine, and aquaporin-1 (AQP-1) were measured. The effects of MTX and protective properties of zingerone on oxidative stress were investigated through the measurement of malondialdehyde and reduced glutathione (GSH) levels, catalase (CAT), and glutathione peroxidase (GPx) enzyme activities. The anti-inflammatory effect of zingerone was determined by measuring the cytokine levels causing inflammation such as nuclear factor-kappa B (NF-kappa B), tumor necrosis factor-alpha (TNF-alpha), and interleukin-1 beta (IL-1 beta), and its effects on apoptosis were determined by immunohistochemical analysis of caspase-3 and B-cell lymphoma-2 (Bcl-2) expression levels. According to the results obtained within the scope of the study, it was determined that zingerone treatment prevented the increase in MTX-induced liver and kidney function markers, showed healing effects on antioxidant parameters degraded in both tissues, and decreased the inflammation parameters. It was determined that it also prevented apoptosis and possessed a protective effect on disrupted tissue architecture by decreasing the increased caspase-3 expression and increasing the decreased Bcl-2 level.en_US
dc.description.sponsorshipUnit of Scientific Research Projects of Mustafa Kemal University [18.M(0).085]en_US
dc.description.sponsorshipThis research was supported by the Unit of Scientific Research Projects of Mustafa Kemal University [Project number 18.M(0).085].en_US
dc.identifier.doi10.1080/01480545.2020.1804397
dc.identifier.endpage1065en_US
dc.identifier.issn0148-0545
dc.identifier.issn1525-6014
dc.identifier.issue3en_US
dc.identifier.pmid32781857en_US
dc.identifier.scopus2-s2.0-85089445638en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1054en_US
dc.identifier.urihttps://doi.org/10.1080/01480545.2020.1804397
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11153
dc.identifier.volume45en_US
dc.identifier.wosWOS:000558504600001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofDrug and Chemical Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMethotrexateen_US
dc.subjectzingeroneen_US
dc.subjectoxidative stressen_US
dc.subjectinflammationen_US
dc.subjectapoptosisen_US
dc.titleZingerone protects liver and kidney tissues by preventing oxidative stress, inflammation, and apoptosis in methotrexate-treated ratsen_US
dc.typeArticleen_US

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